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| Nomenclature |
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Symbol:
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Akt1tm1Mbb
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Name:
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thymoma viral proto-oncogene 1;
targeted mutation 1, Morris Birnbaum
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MGI ID: |
MGI:2180150 |
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Synonyms: |
Akt- |
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Gene:
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Akt1
Location:
Chr12:113892039-113913095 bp, - strand
Genetic Position: Chr12,
57.0 cM, cytoband F1-F2
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:72176
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A neomycin resistance gene was used to replace exons 4 through 7 and the 5' portion of exon 8. Exon 5 is known to encode an lysine residue essential for catalytic activity. Expression was undetected in homozygous mutant animals by both Northern and Western blot analyses. The authors noted that the expression of Akt2 and Akt3 was normal in mice homozygous for the targeted allele. (J:72176) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
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expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:72176
Cho H et al.,
"Akt1/pkbalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice."
J Biol Chem 2001 Oct 19;276(42):38349-52
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All: |
24 reference(s)
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