Tg(Camk2a-tTA)1Mmay Transgene Detail MGI Mouse (MGI:2179066)

Tg(Camk2a-tTA)1Mmay
Transgene Detail

Nomenclature

Symbol:	Tg(Camk2a-tTA)1Mmay
Name:	transgene insertion 1, Mark Mayford
MGI ID:	MGI:2179066
Synonyms:	CamDAT, CAMK-rTA, CaMKIIalpha-tTA, pCaMKII-tTA, Tg(alphacre), Tg^{(CaMKIItTA)Mmay}, Tg^{alpha-CaMkII-tTA}
Transgene:	Tg(Camk2a-tTA)1Mmay Location: unknown

Transgene
origin

Strain of Origin:

Not Specified

Transgene
description

Transgene Type:	Transgenic (random, expressed)
Mutation:	Insertion
	The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. (J:37107)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:

Mouse Strains: 2 strains available Cell Lines: 0 lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems

Genotypes:

behavior/neurological

√

growth/size

√

immune system

√

lethality/prenatal-perinatal

√

life span/aging

√

muscle

√

nervous system

√

other phenotype

√

normal phenotype

Disease Models

√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

cn1

Psmc1^tm1Maye/Psmc1^tm1Maye
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)1Lin/0

involves: 129 * C57BL/6 * CD-1

cn2

Grin1^tm1Rsp/Grin1^tm1Rsp
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-cre)LC1Bjd/?

involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

tg3

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)885Dbo/0

involves: C3H/HeJ * C57BL/6 * CBA

tg4

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0

involves: C3H/HeJ * C57BL/6 * CBA

tg5

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0

involves: C3H/HeJ * C57BL/6 * CBA

tg6 Disease Model

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0

involves: C3H/HeJ * C57BL/6 * CBA

tg7

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-COX8A/EYFP)1Ksn/0

involves: C57BL/6

tg8

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-S100a10)1Pggd/0

involves: C57BL/6

tg9 Disease Model

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-HTT*94Q,-lacZ)1Rhn/0

involves: C57BL/6 * CBA

tg10

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-DISC1*)1001Plet/0

involves: C57BL/6 * CBA * SJL

tg11

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-CDK5R1/GFP)337Lht/0

involves: C57BL/6J

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
			Allelic Composition	Genetic Background
Models involving transgenes or other mutation types.¹
Alzheimer Disease; AD OMIM ID: 104300		tg6	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-APPSwInd)102Dbo/0	involves: C3H/HeJ * C57BL/6 * CBA	J:109829
Huntington Disease; HD OMIM ID: 143100		tg9	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-HTT*94Q,-lacZ)1Rhn/0	involves: C57BL/6 * CBA	J:61490

¹Models involving transgenes or other mutation types may also appear in other sections of the table.

Notes

This transgene is line B.

Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression.

References

Original:	J:37107 Mayford M et al., "Control of memory formation through regulated expression of a CaMKII transgene." Science 1996 Dec 6;274(5293):1678-83
All:	58 reference(s)

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