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Dicer1 Gene Detail
 Symbol
Name
ID
Dicer1
Dicer1, Dcr-1 homolog (Drosophila)
MGI:2177178


Nomenclature History
Synonyms 1110006F08Rik, D12Ertd7e, mKIAA0928
Genetic Map
Chromosome 12
51.0 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr12:105925952-105990162 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Dicer1 ± 2 cM)
TreeFam: TF330258
Sequences
Representative Sequences Length Strain/Species Flank
genomic 192119 NCBI Gene Model | MGI Sequence Detail 64211 C57BL/6J ± Kb
transcript NM_148948 RefSeq | MGI Sequence Detail 9851 -
polypeptide Q8R418 UniProt | EBI | MGI Sequence Detail 1916 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes
All alleles(22) : Targeted, knock-out(6) Targeted, other(7) Gene trapped(9)
Mutation of this locus results in arrest of early embryonic development.
Polymorphisms SNPs within 2kb(335 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(33)
Process angiogenesis, branching morphogenesis of a tube...
Component cytoplasm, intracellular...
Function ATP binding, ATP-dependent helicase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (13 records)
Data Summary: Assays (8)    Results (42)    Tissues (24)    Images (5)
Theiler Stages: 10,16,18,19,21,22,23,25,28
  Assay Type Assays   Results
      Western blot 1   2
      RT-PCR 1   12
      RNA in situ 3   8
      Northern blot 3   20
cDNA source data(14)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(22) cDNA(14) Primer pair(6) Other(2) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000041415
DoTS DT.101150704, DT.101307454, DT.40140525, DT.528104, DT.91352884
PDB 3C4B, 3C4T
DFCI TC1577504, TC1615862, TC1629974, TC1642847
NIA Mouse Gene Index U034309
Entrez Gene 192119
International Mouse Knockout Project Status Dicer1
Protein
domains
InterPro ID Description
IPR000999 Ribonuclease III
IPR001159 Double-stranded RNA binding
IPR001650 DNA/RNA helicase, C-terminal
IPR003100 Argonaute/Dicer protein, PAZ
IPR005034 Dicer double-stranded RNA-binding fold
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 DEAD-like helicase, N-terminal
IPR014021 Helicase, superfamily 1/2, ATP-binding domain
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS et al., "Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development." Development 2000 Apr;127(8):1737-49
(Latest) J:153927 Sekine S et al., "Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis." Gastroenterology 2009 Jun;136(7):2304-2315.e1-4
All references(76)
Other
accession IDs
MGI:1098649, MGI:1915712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory