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| Nomenclature |
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Symbol:
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Selplgtm1Fur
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Name:
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selectin, platelet (p-selectin) ligand;
targeted mutation 1, Bruce Furie
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MGI ID: |
MGI:2176571 |
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Synonyms: |
PSGL-1- |
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Gene:
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Selplg
Location:
Chr5:114268561-114280442 bp, - strand
Genetic Position: Chr5,
64.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:75412
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A neomycin resistance cassette replaced a small DNA segment of the coding region (+69 to 94). A 300 bp segment in the 5' flanking region containing CT repeats was also deleted. Northern blot analysis on thymus and spleen RNA from homozygous mice demonstrated that no detecable transcript was produced from this allele. Flow cytometry experiments on leukocytes derived from homozygous mice confirmed that no detectable cell surface protein was expressed from this allele. (J:75412) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:75412
Yang J et al.,
"Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration."
J Exp Med 1999 Dec 20;190(12):1769-82
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All: |
25 reference(s)
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