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| Nomenclature |
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Symbol:
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Chst3tm1Tmu
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Name:
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carbohydrate (chondroitin 6/keratan) sulfotransferase 3;
targeted mutation 1, Takashi Muramatsu
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MGI ID: |
MGI:2176247 |
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Synonyms: |
C6st- |
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Gene:
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Chst3
Location:
Chr10:59644282-59651455 bp, - strand
Genetic Position: Chr10,
cytoband C
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:73698
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutation: |
Disruption caused by insertion of vector |
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A neomycin resistance cassette replaced sequences in exon III encoding part of the catalytic domain. Northern blot analysis of spleen did not detect mRNA in homozygous mutant mice. Protein activity was not detected in spleen, lung, and lymph nodes of homozygous mutant mice. (J:73698) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Chst3tm1Tmu/Chst3tm1Tmu |
involves: 129S2/SvPas * 129X1/SvJ |
immune system nervous system hematopoietic system |
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| References |
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Original: |
J:73698
Uchimura K et al.,
"Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates."
J Biol Chem 2002 Jan 11;277(2):1443-50
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All: |
1 reference(s)
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