Bcl3<tm1Sbn> Targeted Allele Detail MGI Mouse (MGI:2158443)

Bcl3^tm1Sbn
Targeted Allele Detail

Nomenclature

Symbol:	Bcl3^tm1Sbn
Name:	B-cell leukemia/lymphoma 3; targeted mutation 1, Ulrich Siebenlist
MGI ID:	MGI:2158443
Synonyms:	Bcl3^-
Gene:	Bcl3 Location: Chr7:20393811-20408119 bp, - strand Genetic Position: Chr7, 6.5 cM

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39747
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:	Targeted (knock-out)
Mutations:	Insertion, Intragenic deletion
	A genomic fragment containing the coding sequences for most of the ankyrin repeat-encoding exons was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:39747)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Bcl3 Mutation:	28 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

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Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1
hematopoietic system		√
decreased macrophage cell number		√
abnormal lymphocyte morphology		√
decreased B cell number		√
abnormal B cell differentiation		√
abnormal class switch recombination		√
abnormal metallophillic macrophage morphology		√
abnormal spleen marginal zone macrophage morphology		√
intermingled spleen red and white pulp		√
abnormal spleen B cell follicle morphology		√
absent spleen germinal center		√
decreased spleen germinal center size		√
		hm1
homeostasis/metabolism		√
abnormal nitric oxide homeostasis		√
		hm1
immune system		√
decreased macrophage cell number		√
abnormal lymphocyte morphology		√
decreased B cell number		√
abnormal B cell differentiation		√
abnormal class switch recombination		√
abnormal metallophillic macrophage morphology		√
abnormal spleen marginal zone macrophage morphology		√
intermingled spleen red and white pulp		√
abnormal spleen B cell follicle morphology		√
absent spleen germinal center		√
decreased spleen germinal center size		√
abnormal lymph node B cell domain		√
lymph node hypoplasia		√
decreased IgG2a level		√
abnormal cytotoxic T cell physiology		√
decreased interferon-gamma secretion		√
decreased interleukin-12 secretion		√
increased susceptibility to parasitic infection		√
		hm1
life span/aging		√
increased sensitivity to induced morbidity/mortality		√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

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Genotype

Allelic Composition

Genetic Background

hm1

involves: 129S4/SvJae * C57BL/6

References

Original:	J:39747 Franzoso G et al., "Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions." Immunity 1997 Apr;6(4):479-90
All:	8 reference(s)

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