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Ptentm1Hwu
Targeted Allele Detail

Nomenclature
Symbol: Ptentm1Hwu
Name: phosphatase and tensin homolog; targeted mutation 1, Hong Wu
MGI ID: MGI:2156086
Synonyms: Ptenfl, Ptenflox, Ptenfx, Ptenloxp
Gene: Pten   Location: Chr19:32831987-32900650 bp, + strand    Genetic Position: Chr19, 24.5 cM
Mutation
origin
Germline Transmission: Earliest citation of germline transmission: J:75117
Parent Cell Line: LW1 (ES Cell)
Strain of Origin: 129S4/SvJae
Mutation
description
Allele Type: Targeted (Floxed/Frt)
Mutation: Insertion
  A loxP flanked hygromycin resistance cassette was inserted 5' to exon 5, and a single loxP site was inserted 3' to exon 5, which encodes the phosphatase domain. The hygromycin cassette was removed in ES cells by transient Cre recombinase expression prior to the production of chimeric mice, leaving a single loxP site in place of the cassette. These insertions do not appear to have any effect on the normal function of the gene. (J:75117)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation: 30 strains or lines available
Phenotype
summary
help icon
Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
ht1
 
cn2
 
cn3
 
cn4
 
cn5
 
cn6
 
cn7
 
cn8
 
cn9
 
cn10
 
cn11
 
cn12
 
cn13
 
cn14
  
behavior/neurological          		          √   
  
endocrine/exocrine glands          		            √ 
  
hematopoietic system          		        √     
  
homeostasis/metabolism          		          √   
  
immune system          		        √     
  
lethality/postnatal          		            √ 
  
life span/aging          		  √√√√√√    √√
  
nervous system          		          √   
  
reproductive system          		  √    √    √ 
  
skin/coat/nails          		            √ 
  
taste/olfaction          		          √   
  
tumorigenesis          		√√√√√√√√ √N√√√
 
  
Disease Models          		  √   √√    √ 
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 ht1   		 Ptentm1Hwu/Pten+ involves: 129S4/SvJae * BALB/c
  
 cn2   		 Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0		 involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2
  
 cn3   Disease Model  		 Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		 involves: 129 * C57BL/6
  
 cn4   		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char
Ptentm1Hwu/Ptentm1Hwu		 involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
  
 cn5   		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char
Ptentm1Hwu/Ptentm1Hwu		 involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
  
 cn6   		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char
Ptentm1Hwu/Ptentm1Hwu		 involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
  
 cn7   Disease Model  		 Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
  
 cn8   Disease Model  		 Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
  
 cn9   		 Bcl2l11tm1.1Ast/Bcl2l11+
Ptentm1Hwu/Pten+
Tg(CD2-cre)4Kio/0		 involves: 129S1/Sv * 129S4/SvJae * C57BL/10 * CBA/Ca
  
 cn10   		 Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
  
 cn11   		 Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0		 involves: 129S4/SvJae * BALB/c
  
 cn12   		 Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0		 involves: 129S4/SvJae * C57BL/6 * DBA/2
  
 cn13   Disease Model  		 Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)Smr/0		 involves: 129S4/SvJae * C57BL/6J * SJL/J
  
 cn14   		 Ptentm1Hwu/Pten+
Tg(KRT14-cre)Smr/0		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models with phenotypic similarity to human diseases associated with human PTEN.
Cowden Disease; CD
OMIM ID: 158350		 1
 
cn13		Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)Smr/0		involves: 129S4/SvJae * C57BL/6J * SJL/JJ:138927
Models with phenotypic similarity to human diseases not associated with human PTEN.
Bladder Cancer
OMIM ID: 109800		 1
 
cn7		Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVBJ:146760
Endometrial Cancer
OMIM ID: 608089		 1
 
cn8		Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J:139053
1
 
cn3		Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		involves: 129 * C57BL/6J:139053
1Conditionally targeted allele(s).
References
Original: J:75117 Lesche R et al., "Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene." Genesis 2002 Feb;32(2):148-9
All: 72 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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11/20/2009
MGI_4.31
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