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| Nomenclature |
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Symbol:
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Prkcetm1Msg
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Name:
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protein kinase C, epsilon;
targeted mutation 1, Robert Messing
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MGI ID: |
MGI:2152043 |
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Synonyms: |
PKC-epsilon-, PKCepsilon- |
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Gene:
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Prkce
Location:
Chr17:86567125-87057259 bp, + strand
Genetic Position: Chr17,
Syntenic
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:57887
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Parent Cell Line:
| RF8 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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1.2 kb of this gene including the translation initiation site was deleted via homologous recombination with a neo-derived targeting vector. Western blot indicated homozygous mutant animals did not express protein in dorsal root ganglion. (J:57887) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:57887
Khasar SG et al.,
"A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice."
Neuron 1999 Sep;24(1):253-60
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All: |
26 reference(s)
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