About   Help   FAQ
Tour our new Quick Search
Calca Gene Detail
 Symbol
Name
ID
Calca
calcitonin/calcitonin-related polypeptide, alpha
MGI:2151253

Nomenclature History
Synonyms alpha CGRP, CA, Calc, Cgrp, CT, Ct, Ctn
Genetic Map
Chromosome 7
54.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 13)

Sequence Map
Chr7:121775005-121779804 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Calca ± 2 cM)
Protein SuperFamily: calcitonin/calcitonin gene-related protein/amylin
TreeFam: TF333069
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12310 NCBI Gene Model | MGI Sequence Detail 4800 C57BL/6J ± Kb
transcript NM_001033954 RefSeq | MGI Sequence Detail 1022 C57BL/6
polypeptide P70160 UniProt | EBI | MGI Sequence Detail 136 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(2) Targeted, other(2)
Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(57 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process activation of adenylate cyclase activity, activation of adenylate cyclase activity by G-protein signaling pathway...
Component axon, cell soma...
Function calcitonin receptor binding, hormone activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (98 records)
Data Summary: Assays (5)    Results (18)    Tissues (9)    Images (9)
Theiler Stages: 22,24,26,28
  Assay Type Assays   Results
      RNA in situ 1   1
      Immunohistochemistry 4   17
cDNA source data(35)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(38) cDNA(37) Primer pair(1) Antibodies(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030669
DoTS DT.491467, DT.87033494, DT.94228656
Consensus CDS Project CCDS21762.1, CCDS21763.1
UniGene 4361
DFCI TC1584330, TC1585668
NIA Mouse Gene Index U029153
Entrez Gene 12310
International Mouse Knockout Project Status Calca
Protein
domains
InterPro ID Description
IPR001693 Calcitonin peptide-like
IPR001935 Calcitonin peptide, alpha type
IPR002163 Calcitonin gene related peptide, CGRP
IPR018360 Calcitonin, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:6525 Jacobs JW et al., "Calcitonin messenger RNA encodes multiple polypeptides in a single precursor." Science 1981 Jul 24;213(4506):457-9
(Latest) J:154238 Becklund BR et al., "The calcitonin/calcitonin gene related peptide-alpha gene is not required for 1alpha,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis." Arch Biochem Biophys 2009 Aug 15;488(2):105-8
All references(182)
Other
accession IDs 		MGD-MRK-1732, MGD-MRK-2210, MGD-MRK-2239, MGI:1101063, MGI:88249
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory