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| Nomenclature |
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Symbol:
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Mecp2tm1.1Bird
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Name:
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methyl CpG binding protein 2;
targeted mutation 1.1, Adrian Bird
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MGI ID: |
MGI:2137311 |
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Synonyms: |
MeCP2Bird |
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Gene:
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Mecp2
Location:
ChrX:71271931-71331029 bp, - strand
Genetic Position: ChrX,
29.6 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:67910
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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Insertion of a neomycin resistance cassette into the Mecp2 gene introduced loxP sites that flank exons 3 and 4, and added an intron and polyadenylation signal from the human beta globin gene. A CMV-Cre mediated recombination event in the germline then removed exons 3 and 4. Northern blot analysis did not detect Mecp2 mRNA in tissues of mutant male mice (-/y), nor did Western blot analysis detect protein in these tissues. (J:67910) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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| References |
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Original: |
J:67910
Guy J et al.,
"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome."
Nat Genet 2001 Mar;27(3):322-6
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All: |
36 reference(s)
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