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| Nomenclature |
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Symbol:
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Car2n
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Name:
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carbonic anhydrase 2;
null
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MGI ID: |
MGI:2135646 |
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Synonyms: |
CA(II)D, CAII-, Car-20, Car2-, Car2N |
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Gene:
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Car2
Location:
Chr3:14886725-14900769 bp, + strand
Genetic Position: Chr3,
10.5 cM
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Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Mutation
description |
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Allele
Type: |
Chemically induced (ENU) |
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Mutation: |
Undefined |
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The result of ENU mutagenesis, the mutation at the Car2 locus is likely a nonsense or missense mutation. Molecular analysis shows that the mutant gene is not deleted but is transcribed. The CAR2 protein could not be detected by immunodiffusion analysis and Southern analysis indicates no detectable rearrangements or polymorphisms. (J:19268) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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| References |
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Original: |
J:19268
Lewis SE et al.,
"N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome."
Proc Natl Acad Sci U S A 1988 Mar;85(6):1962-6
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All: |
18 reference(s)
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