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Cblc Gene Detail
 Symbol
Name
ID
Cblc
Casitas B-lineage lymphoma c
MGI:1931457


Nomenclature History
Synonyms 2310076I21Rik, 2310079L19Rik, Cbl3
Genetic Map
Chromosome 7
cytoband A2
 
Mapping data( 2)
Sequence Map
Chr7:20364230-20382158 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: E3 ubiquitin-protein ligase Cbl
TreeFam: TF314210
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000029153 VEGA Gene Model | MGI Sequence Detail 17929 C57BL/6J ± Kb
transcript NM_023224 RefSeq | MGI Sequence Detail 1677 C57BL/6
polypeptide Q80XL1 UniProt | EBI | MGI Sequence Detail 496 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(6) : Targeted, other(1) Gene trapped(5)
Homozygous null mice are viable, fertile, and show no abnormalities of the epithelium or other tissues.
Polymorphisms SNPs within 2kb(75 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell surface receptor linked signal transduction, ubiquitin-dependent protein catabolic process...
Component nucleus, ubiquitin ligase complex...
Function calcium ion binding, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (4)    Results (26)    Tissues (22)    Images (1)
Theiler Stages: 10,18,21,22,23,25,28
  Assay Type Assays   Results
      RNA in situ 2   14
      Northern blot 2   12
cDNA source data(31)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(33) cDNA(33)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000040525
DoTS DT.60110613, DT.94269620
Consensus CDS Project CCDS39804.1
UniGene 81698
DFCI TC1582823, TC1596246
NIA Mouse Gene Index U028241
Entrez Gene 80794
VEGA Gene Model OTTMUSG00000029153
International Mouse Knockout Project Status Cblc
Protein
domains
InterPro ID Description
IPR000980 SH2 motif
IPR001841 Zinc finger, RING-type
IPR003153 Adaptor protein Cbl, N-terminal helical
IPR011992 EF-hand-like domain
IPR014741 Adaptor protein Cbl, EF hand-like
IPR014742 Adaptor protein Cbl, SH2-like
IPR017907 Zinc finger, RING-type, conserved site
IPR018957 Zinc finger, C3HC4 RING-type
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:147711 Dale BM et al., "Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding." J Immunol 2009 May 1;182(9):5654-62
All references(9)
Other
accession IDs
MGI:1913812, MGI:1919198

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory