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Trp53tm1Brn
Targeted Allele Detail

Nomenclature
Symbol: Trp53tm1Brn
Name: transformation related protein 53; targeted mutation 1, Anton Berns
MGI ID: MGI:1931011
Synonyms: p53F, p53Fl, p53flox, p53L, p53lox, p53LoxP, Trp53F2-10, Trp53F2-F10, Trp53Fl
Gene: Trp53   Location: Chr11:69393861-69405375 bp, + strand    Genetic Position: Chr11, 39.0 cM, cytoband B2-C
Mutation
origin
Germline Transmission: Earliest citation of germline transmission: J:61961
Parent Cell Line: IB10/E14IB10 (ES Cell)
Strain of Origin: 129P2/OlaHsd
Mutation
description
Allele Type: Targeted (Floxed/Frt)
Mutation: Insertion
  Insertion of loxP sites flanking exons 2 through 10. No effect on the normal function of the gene. (J:61961)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation: 125 strains or lines available
Phenotype
summary
help icon
Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
hm1
 
cn2
 
cn3
 
cn4
 
cn5
 
cn6
 
cn7
 
cn8
 
cn9
 
cn10
 
cn11
 
cn12
 
cn13
 
cn14
 
cn15
 
cn16
 
cn17
 
cn18
 
cn19
 
cn20
 
cn21
 
cn22
 
cn23
 
cn24
 
cn25
 
cn26
 
cn27
 
cn28
 
cn29
 
cn30
 
cn31
 
cn32
 
cn33
 
cn34
 
cn35
 
cn36
 
cn37
 
cn38
 
cn39
 
cn40
 
cn41
 
cn42
 
cn43
 
cn44
  
behavior/neurological          		                      √          √          
  
cardiovascular system          		                                    √√      
  
cellular          		 √    √N        √               √           
  
life span/aging          		  √       √          √ √√√√      √          
  
liver/biliary system          		                        √ √                 
  
nervous system          		                      √                     
  
reproductive system          		  √         N                               
  
respiratory system          		        √                                   
  
skin/coat/nails          		                                √  √√√√  √√√
  
tumorigenesis          		  √√√√  √√√√ √√√√√√√√√√√√√√√√√√√√√√√√√√√ √√√
  
vision/eye          		               √√√                          
  
normal phenotype          		N                                       N   
 
  
Disease Models          		  √          √√      √ √√  √ √√√√      √ √  
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 hm1   		 Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * FVB/N
  
 cn2   		 Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd
  
 cn3   Disease Model  		 Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		 involves: 129 * C57BL/6
  
 cn4   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53+
Tg(KRT5-cre/PGR)1Der/?		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
  
 cn5   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm3Glo
Tg(KRT5-cre/PGR)1Der/?		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
  
 cn6   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT5-cre/PGR)1Der/?		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR
  
 cn7   		 Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd
  
 cn8   		 Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Htr/Rbl1+
Trp53tm1Brn/Trp53tm1Brn
Tg(En2-cre)22Alj/0		 involves: 129P2/OlaHsd
  
 cn9   		 Braftm1Mmcm/Braf+
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd
  
 cn10   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53+		 involves: 129P2/OlaHsd
  
 cn11   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd
  
 cn12   		 Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0		 involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
  
 cn13   		 Pgrtm2(cre)Lyd/Pgr+
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
  
 cn14   Disease Model  		 Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53+		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
  
 cn15   Disease Model  		 Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
  
 cn16   		 Rb1tm1Tyj/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
  
 cn17   		 Rb1tm1Tyj/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Trp53tm1Brn/Trp53tm1Tyj
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
  
 cn18   		 Rb1tm1Tyj/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1+
Trp53tm1Brn/Trp53tm1Brn
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
  
 cn19   		 Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
  
 cn20   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm2Tyj		 involves: 129P2/OlaHsd * 129S4/SvJae
  
 cn21   		 Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S4/SvJae
  
 cn22   Disease Model  		 Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
  
 cn23   		 Ptentm1Rdp/Pten+
Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre)25Mes/0		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N
  
 cn24   Disease Model  		 Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn25   Disease Model  		 Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn26   		 Nf2tm2Gth/Nf2+
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn27   		 Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53+		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn28   Disease Model  		 Cdkn2atm1.1Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn29   		 Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
  
 cn30   Disease Model  		 Brca1tm1Brn/Brca1+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
  
 cn31   Disease Model  		 Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
  
 cn32   Disease Model  		 Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
  
 cn33   Disease Model  		 Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N
  
 cn34   		 Ptentm1Mro/Ptentm1Mro
Tg(KRT14-cre)8Brn/0
Trp53tm1Brn/Trp53tm1Brn		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N
  
 cn35   		 Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre)25Mes/0		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
  
 cn36   		 Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn37   		 Cdh1tm1Jjon/Cdh1tm1Jjon
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn38   		 Cdh1tm1Jjon/Cdh1tm1Jjon
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn39   		 Cdh1tm1Jjon/Cdh1+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn40   Disease Model  		 Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Gfap-cre)2Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn41   		 Trp53tm1Brn/Trp53tm1Brn
Tg(Gfap-cre)2Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn42   Disease Model  		 Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn43   		 Brca2tm1Brn/Brca2+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
  
 cn44   		 Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0		 involves: 129P2/OlaHsd * FVB/N
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models with phenotypic similarity to human diseases associated with human TP53.
Breast Cancer
OMIM ID: 114480		 1
 
cn31		Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0		involves: 129P2/OlaHsd * BALB/cJ * FVB/NJ:126551
1
 
cn30		Brca1tm1Brn/Brca1+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		involves: 129P2/OlaHsd * BALB/cJ * FVB/NJ:126551
1
 
cn32		Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		involves: 129P2/OlaHsd * BALB/cJ * FVB/NJ:126551
1
 
cn42		Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0		involves: 129P2/OlaHsd * FVB/NJ:73028
Models with phenotypic similarity to human diseases not associated with human TP53.
Bladder Cancer
OMIM ID: 109800		 1
 
cn22		Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVBJ:146760
Endometrial Cancer
OMIM ID: 608089		 1
 
cn3		Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn		involves: 129 * C57BL/6J:139053
Medulloblastoma; MDB
OMIM ID: 155255		 1
 
cn40		Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Gfap-cre)2Brn/0		involves: 129P2/OlaHsd * FVB/NJ:61961
Mesothelioma, Malignant
OMIM ID: 156240		 1
 
cn24		Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S7/SvEvBrdJ:132943
1
 
cn28		Cdkn2atm1.1Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S7/SvEvBrdJ:132943
1
 
cn25		Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S7/SvEvBrdJ:132943
Rhabdomyosarcoma 2; RMS2
OMIM ID: 268220		 1
 
cn15		Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJLJ:93444
1
 
cn14		Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Trp53tm1Brn/Trp53+		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJLJ:93444
Squamous Cell Carcinoma, Head and Neck; HNSCC
OMIM ID: 275355		 1
 
cn33		Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/NJ:144831
1Conditionally targeted allele(s).
2BRCA2 is associated with this disease in humans.
3PAX3 is associated with this disease in humans.
References
Original: J:61961 Marino S et al., "Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum." Genes Dev 2000 Apr 15;14(8):994-1004
All: 63 reference(s)
Contributing Projects:
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11/20/2009
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