|
|
| Nomenclature |
|
Symbol:
|
Tg(Trp53R172L)4491Jmr
|
|
Name:
|
transgenic nonhomologous insert 4491, Jeffrey Rosen;
transgene insertion 4491, Jeffrey Rosen
|
|
MGI ID: |
MGI:1929643 |
|
Transgene:
|
Tg(Trp53R172L)4491Jmr
Location:
unknown
|
|
Transgene
origin |
|
Transgene
description |
|
Transgene
Type: |
Transgenic (random, expressed) |
|
Mutation: |
Insertion |
| |
This transgene contains the rat whey acidic protein promoter (0.95 kb of 5' sequence) fused to a mouse Trp53 minigene that carries a transversion in codon 172 (CGC->CTC; "Arg172Leu"). Removal of the ts mutation in the original Trp53 minigene at codon 135 (Ala-Val) and introduction of the Arg-Leu mutation at amino acid 172 were accomplished using recombinant PCR mutagenesis. (J:56433) |
|
Inheritance: |
Not Specified |
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Phenotype
summary
|
|
Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
|
Key:
|
| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
|
|
|
|
|
Phenotypic
data by
genotype
|
|
Phenotypic Data by Genotype
(show or
hide all phenotypic details)
|
|
|
|
| References |
|
Original: |
J:56433
Li B et al.,
"Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development."
Cell Growth Differ 1994 Jul;5(7):711-21
|
|
All: |
2 reference(s)
|
|
