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| Nomenclature |
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Symbol:
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Tg(Trp53R172H)8512Jmr
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Name:
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transgenic nonhomologous insert 8512, Jeffrey Rosen;
transgene insertion 8512, Jeffrey Rosen
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MGI ID: |
MGI:1929642 |
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Synonyms: |
172R-H, p53-172H |
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Transgene:
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Tg(Trp53R172H)8512Jmr
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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This transgene contains the rat whey acidic protein promoter and an allele of the mouse Trp53 mini-gene that carries a point mutation in codon 172 (CGC->CAC; Arg172His). (J:46426) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Notes |
On an FVB/N background transgenic mice express TRP53 with both dominant-negative and a gain-of function properties.
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| References |
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Original: |
J:46426
Li B et al.,
"A transgenic mouse model for mammary carcinogenesis."
Oncogene 1998 Feb 26;16(8):997-1007
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All: |
7 reference(s)
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