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| Nomenclature |
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Symbol:
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Nrgntm1Kph
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Name:
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neurogranin;
targeted mutation 1, Kuo-Ping Huang
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MGI ID: |
MGI:1927195 |
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Synonyms: |
Ng- |
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Gene:
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Nrgn
Location:
Chr9:37352550-37360294 bp, - strand
Genetic Position: Chr9,
17.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:65166
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: |
Targeted (Reporter) |
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Mutation: |
Insertion |
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Insertion of a LacZ gene in frame into the first coding exon, followed by a neomycin cassette. No NRGN immunoreactivity was detected in brain sections derived from homozygous mutant mice. X-gal staining in homozygous mutant mice corresponded with the NRGN positive staining in wild-type mice. (J:65166) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:65166
Pak JH et al.,
"Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice"
Proc Natl Acad Sci U S A 2000 Oct 10;97(21):11232-7
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All: |
6 reference(s)
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