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Pdk1 Gene Detail
 Symbol
Name
ID
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
MGI:1926119

Nomenclature History
Synonyms D530020C15Rik
Genetic Map
Chromosome 2
Syntenic
 
Mapping data( 1)
Sequence Map
Chr2:71711281-71741915 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
TreeFam: TF314918
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000013264 VEGA Gene Model | MGI Sequence Detail 30635 C57BL/6J ± Kb
transcript NM_172665 RefSeq | MGI Sequence Detail 5137 C57BL/6
polypeptide Q8BFP9 UniProt | EBI | MGI Sequence Detail 434 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(15) : Targeted, other(1) Gene trapped(14)
Polymorphisms SNPs within 2kb(239 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process carbohydrate metabolic process, glucose metabolic process...
Component mitochondrion, plasma membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (94)    Tissues (94)    Images (16)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   94
cDNA source data(143)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(145) Genomic(1) cDNA(143) Primer pair(1)
Microarray probesets(3)
Other database
links
EC 2.7.11.2
Ensembl Gene Model ENSMUSG00000006494
DoTS DT.101715670, DT.40136037, DT.493169, DT.55212099, DT.97353072
Consensus CDS Project CCDS16119.1
UniGene 34411
DFCI TC1574312, TC1589408, TC1605204, TC1616989, TC1663024
NIA Mouse Gene Index U042315
Entrez Gene 228026
VEGA Gene Model OTTMUSG00000013264
International Mouse Knockout Project Status Pdk1
Protein
domains
InterPro ID Description
IPR003594 ATPase-like, ATP-binding domain
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:153995 Waugh C et al., "Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation." Mol Cell Biol 2009 Nov;29(21):5952-62
All references(18)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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