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Pik3cb Gene Detail
 Symbol
Name
ID
Pik3cb
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
MGI:1922019

Nomenclature History
Synonyms 1110001J02Rik, p110beta
Genetic Map
Chromosome 9
cytoband E4
 
Mapping data( 2)
Sequence Map
Chr9:98938821-99041040 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: phosphatidylinositol 3-kinase
TreeFam: TF102031
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021081 VEGA Gene Model | MGI Sequence Detail 102220 C57BL/6J ± Kb
transcript NM_029094 RefSeq | MGI Sequence Detail 4854 C57BL/6
polypeptide Q8BTI9 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes 		All alleles(75) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(71)
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
Phenotype Images (1)  
Polymorphisms SNPs within 2kb(499 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular calcium ion homeostasis, embryonic cleavage...
Component phosphoinositide 3-kinase complex
Function 1-phosphatidylinositol-3-kinase activity, ATP binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (2)    Results (12)    Tissues (12)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      Northern blot 2   12
cDNA source data(41)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(42) cDNA(42)
Microarray probesets(1)
Other database
links
EC 2.7.1.153
Ensembl Gene Model ENSMUSG00000032462
DoTS DT.101718468, DT.87068643, DT.97386104
Consensus CDS Project CCDS23432.1
UniGene 213128
DFCI TC1579745, TC1677871
NIA Mouse Gene Index U031230
Entrez Gene 74769
VEGA Gene Model OTTMUSG00000021081
International Mouse Knockout Project Status Pik3cb
Protein
domains
InterPro ID Description
IPR000341 Phosphoinositide 3-kinase, ras-binding
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphoinositide 3-kinase, C2
IPR003113 Phosphatidylinositol 3-kinase, p85-binding
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011009 Protein kinase-like domain
IPR015433 Phosphatidylinositol Kinase
IPR016024 Armadillo-type fold
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:155435 Al-Qassab H et al., "Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons." Cell Metab 2009 Nov;10(5):343-54
All references(27)
Other
accession IDs 		MGI:2143049
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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