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Ppp2r2a Gene Detail
 Symbol
Name
ID
Ppp2r2a
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
MGI:1919228

Nomenclature History
Synonyms 2410004D02Rik
Genetic Map
Chromosome 14
cytoband D1
 
Mapping data( 2)
Sequence Map
Chr14:67632894-67691281 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: serine/threonine-protein phosphatase 2A, subunit B55
TreeFam: TF105553
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000022052 Ensembl Gene Model | MGI Sequence Detail 58388 C57BL/6J ± Kb
transcript NM_028032 RefSeq | MGI Sequence Detail 2380 C57BL/6
polypeptide Q6P1F6 UniProt | EBI | MGI Sequence Detail 447 Not Applicable
For the selected sequences
All sequences(37)
Alleles
and
phenotypes 		All alleles(39) : Targeted, other(4) Gene trapped(35)
Polymorphisms SNPs within 2kb(268 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process response to morphine, signal transduction...
Component protein phosphatase type 2A complex
Function protein phosphatase type 2A regulator activity
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (4)    Results (16)    Tissues (8)
Theiler Stages: 23,28
  Assay Type Assays   Results
      Western blot 1   4
      RT-PCR 2   8
      Immunohistochemistry 1   4
cDNA source data(144)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(146) cDNA(144) Primer pair(2) Antibodies(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022052
DoTS DT.101351720, DT.101394544, DT.101737180, DT.55138875
UniGene 273997
DFCI TC1572718, TC1631087, TC1650142
NIA Mouse Gene Index U035710, U118667
Entrez Gene 71978
International Mouse Knockout Project Status Ppp2r2a
Protein
domains
InterPro ID Description
IPR000009 Protein phosphatase 2A, regulatory subunit PR55
IPR001680 WD40 repeat
IPR011046 WD40 repeat-like-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR018067 Protein phosphatase 2A, regulatory subunit PR55, conserved site
IPR019781 WD40 repeat, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:153617 O'Shaughnessy RF et al., "Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development." Development 2009 Oct;136(20):3423-31
All references(11)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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