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Pak4 Gene Detail
 Symbol
Name
ID
Pak4
p21 protein (Cdc42/Rac)-activated kinase 4
MGI:1917834


Nomenclature History
Synonyms 5730488L07Rik, mKIAA1142
Genetic Map
Chromosome 7
Syntenic
 
Mapping data( 2)
Sequence Map
Chr7:29343838-29383204 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF105352
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000025040 VEGA Gene Model | MGI Sequence Detail 39367 C57BL/6J ± Kb
transcript NM_027470 RefSeq | MGI Sequence Detail 2898 C57BL/6
polypeptide Q8BTW9 UniProt | EBI | MGI Sequence Detail 593 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(104) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(101)
Homozygous null mice die at midgestation exhibiting heart defects as well as impaired neuronal development and yolk sac vasculature.
Polymorphisms SNPs within 2kb(120 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process protein amino acid phosphorylation
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (96)    Tissues (94)    Images (11)
Theiler Stages: 22,28
  Assay Type Assays   Results
      Western blot 1   3
      RNA in situ 1   93
cDNA source data(62)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(63) cDNA(62) Primer pair(1) Antibodies(1)
Microarray probesets(1)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000030602
DoTS DT.101373909, DT.87072376
Consensus CDS Project CCDS21049.1
UniGene 21876
DFCI TC1577262
NIA Mouse Gene Index U028328
Entrez Gene 70584
VEGA Gene Model OTTMUSG00000025040
International Mouse Knockout Project Status Pak4
Protein
domains
InterPro ID Description
IPR000095 PAK-box/P21-Rho-binding
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR011009 Protein kinase-like domain
IPR015750 Serine/threonine-protein kinase, Pak-related
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:152821 Tian Y et al., "Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation." Mech Dev 2009 Aug-Sep;126(8-9):710-20
All references(12)
Other
accession IDs
MGI:2142263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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