About   Help   FAQ
Dkk2 Gene Detail
 Symbol
Name
ID
Dkk2
dickkopf homolog 2 (Xenopus laevis)
MGI:1890663


Nomenclature History
Genetic Map
Chromosome 3
cytoband H2
 
Mapping data( 2)
Sequence Map
Chr3:131748265-131843257 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: Dickkopf-related protein Dkk-1/Dkk-2
TreeFam: TF330916
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000028031 Ensembl Gene Model | MGI Sequence Detail 94993 C57BL/6J ± Kb
transcript NM_020265 RefSeq | MGI Sequence Detail 3705 -
polypeptide Q9QYZ8 UniProt | EBI | MGI Sequence Detail 259 Not Applicable
For the selected sequences
All sequences(15)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Gene trapped(1)
mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture.
Polymorphisms SNPs within 2kb(551 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process multicellular organismal development, negative regulation of Wnt receptor signaling pathway...
Component extracellular region
External Resources: FuncBase
Expression Literature Summary: (19 records)
Data Summary: Assays (10)    Results (243)    Tissues (205)    Images (44)
Theiler Stages: 1,2,3,4,5,8,9,11,13,15,16,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 3   38
      RNA in situ 6   203
      Immunohistochemistry 1   2
cDNA source data(20)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(29) cDNA(21) Primer pair(8) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000028031
DoTS DT.101725968
Consensus CDS Project CCDS17844.1
UniGene 103593
PDB 2JTK
DFCI TC1582753
NIA Mouse Gene Index U003863
Entrez Gene 56811
International Mouse Knockout Project Status Dkk2
Protein
domains
InterPro ID Description
IPR006796 Dickkopf, N-terminal cysteine-rich
Graphical View of Protein Domain Structure
References
(Earliest) J:57798 Monaghan AP et al., "Dickkopf genes are co-ordinately expressed in mesodermal lineages." Mech Dev 1999 Sep;87(1-2):45-56
(Latest) J:155223 Suomalainen M et al., "Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells." Dev Dyn 2009 Oct 5;239(1):364-372
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory