Tg(Wnt1)1Hev Transgene Detail MGI Mouse (MGI:1890080)

Tg(Wnt1)1Hev
Transgene Detail

Nomenclature

Symbol:	Tg(Wnt1)1Hev
Name:	transgene insertion 1, Harold E Varmus
MGI ID:	MGI:1890080
Synonyms:	line 303, MMTV-Wnt-1, Wnt-1
Transgene:	Tg(Wnt1)1Hev Location: unknown

Transgene
origin

Strain of Origin:

C57BL/6 x SJL

Transgene
description

Transgene Type:	Transgenic (random, expressed)
Mutation:	Insertion
	Wnt1 is driven by the mouse mammary tumor virus (MMTV). The construct resembles alleles found in virus-induced tumors. (J:28473)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:

Mouse Strains: 2 strains available Cell Lines: 0 lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8
endocrine/exocrine glands		√	√	√	√	√
abnormal mammary gland morphology		√
abnormal branching of the mammary ductal tree		√	√	√	√
abnormal mammary gland lobule morphology		√
mammary gland alveolar hyperplasia		√
mammary gland hyperplasia			√	√	√	√
		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8
reproductive system		√	√	√	√	√
abnormal mammary gland morphology		√
abnormal branching of the mammary ductal tree		√	√	√	√
abnormal mammary gland lobule morphology		√
mammary gland alveolar hyperplasia		√
mammary gland hyperplasia			√	√	√	√
		tg1	tg2	tg3	tg4	tg5	tg6	tg7	tg8
tumorigenesis			√	√	√	√	√	√	√
mammary gland tumor			√	√	√
mammary adenocarcinoma									√
decreased tumor incidence						√	√
decreased tumor growth/size								√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
tg1	Tg(Wnt1)1Hev/0	either: FVB/N or (involves: C57BL/6 * SJL)
endocrine/exocrine glands abnormal mammary gland morphology (J:28473) mammary glands in virgin females resemble hormonally-stimulated glands from pregnant mice abnormal branching of the mammary ductal tree (J:28473) hemizygous transgenic females show a marked increase in the number of terminal branches abnormal mammary gland lobule morphology (J:28473) hemizygous transgenic females display diffuse lobular hyperplasia mammary gland alveolar hyperplasia (J:28473) reproductive system abnormal mammary gland morphology (J:28473) mammary glands in virgin females resemble hormonally-stimulated glands from pregnant mice abnormal branching of the mammary ductal tree (J:28473) hemizygous transgenic females show a marked increase in the number of terminal branches abnormal mammary gland lobule morphology (J:28473) hemizygous transgenic females display diffuse lobular hyperplasia mammary gland alveolar hyperplasia (J:28473)
Genotype	Allelic Composition	Genetic Background
tg2	Tg(Wnt1)1Hev/0	involves: C57BL/6 * FVB * SJL
endocrine/exocrine glands abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia reproductive system abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia tumorigenesis mammary gland tumor (J:96305) develop mammary tumors
Genotype	Allelic Composition	Genetic Background
tg3	Id2^tm1Yyk/Id2^tm1Yyk Tg(Wnt1)1Hev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL
endocrine/exocrine glands abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia reproductive system abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia tumorigenesis mammary gland tumor (J:96305) develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice
Genotype	Allelic Composition	Genetic Background
tg4	Id2^tm1Yyk/Id2⁺ Tg(Wnt1)1Hev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL
endocrine/exocrine glands abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia reproductive system abnormal branching of the mammary ductal tree (J:96305) mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice mammary gland hyperplasia (J:96305) mammary glands of virgin females have extensive, dense hyperplasia tumorigenesis mammary gland tumor (J:96305) develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice
Genotype	Allelic Composition	Genetic Background
tg5	Sdc1^tm1Cma/Sdc1^tm1Cma Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL
tumorigenesis decreased tumor incidence (J:63122) only 3% of hemizygous females expressing the transgene in a Sdc1^tm1Cma null background develop mammary tumors (median time: ~36 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks) these Wnt1-induced tumors are predominantly alveolar adenocarcinomas endocrine/exocrine glands mammary gland hyperplasia (J:63122) hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background reproductive system mammary gland hyperplasia (J:63122) hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background
Genotype	Allelic Composition	Genetic Background
tg6	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL
tumorigenesis decreased tumor incidence (J:63122) 30% of hemizygous females expressing the transgene in a Sdc1^tm1Cma heterozygous null background develop mammary tumors (median time: ~25 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks) these Wnt1-induced tumors are predominantly alveolar adenocarcinomas
Genotype	Allelic Composition	Genetic Background
tg7	Muc1^tm1Gend/Muc1^tm1Gend Tg(Wnt1)1Hev/?	involves: FVB
tumorigenesis decreased tumor growth/size (J:82470) onset of mammary tumors was considerably delayed tumors were P-type
Genotype	Allelic Composition	Genetic Background
tg8	Chek1^tm1Sje/Chek1⁺ Tg(Wnt1)1Hev/0	Not Specified
tumorigenesis mammary adenocarcinoma (J:62919) earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

References

Original:	J:28473 Tsukamoto AS et al., "Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice." Cell 1988 Nov 18;55(4):619-25
All:	33 reference(s)

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