Symbol
Name
ID
|
Apba3
amyloid beta (A4) precursor protein-binding, family A, member 3
MGI:1888527
|
Nomenclature History
|
|
|
Synonyms
|
lin-10, Mint 3, Mint-3, neuron-specific X11L2 protein, neuronal munc18-1-interacting protein 3, X11gamma
|
|
Genetic Map
|
|
Chromosome 10
|
Syntenic
|
|
|
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Mapping data(
2)
|
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(22)
|
Alleles
and
phenotypes
|
All alleles(5) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(3)
| Deletion in mutants causes abnormalities in colon morphology and physiology, increased circulating blood urea nitrogen, and decreased serum chloride, sodium and potassium levels. Surviving homozygotes display diarrhea, postnatal viability and decreased life span. |
|
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Polymorphisms
|
SNPs within 2kb(2 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
cDNA source data(48)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(50)
cDNA(50)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:62652
Borg JP et al.,
"Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting."
J Biol Chem 1998 Nov 27;273(48):31633-6
(Latest)
J:142874
Ho A et al.,
"Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease."
J Neurosci 2008 Dec 31;28(53):14392-400
|
All references(7)
|
Other
accession IDs
|
MGI:2143823
|
