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| Nomenclature |
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Symbol:
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Scarb1tm1Kri
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Name:
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scavenger receptor class B, member 1;
targeted mutation 1, Monty Krieger
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MGI ID: |
MGI:1888384 |
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Synonyms: |
SR-BI, SR-BI KO, SR-BI-, srb1-, srbI- |
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Gene:
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Scarb1
Location:
Chr5:125757457-125821464 bp, - strand
Genetic Position: Chr5,
68.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:44187
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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Replacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette. (J:44187) |
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Inheritance: |
Semidominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:44187
Rigotti A et al.,
"A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism."
Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12610-5
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All: |
55 reference(s)
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