Symbol
Name
ID
|
|
|
Synonyms
|
7330414F15Rik, 8430431H08Rik, GSK-3, GSK-3beta, GSK3
|
|
Genetic Map
|
|
Chromosome 16
|
cytoband B4
|
|
|
|
Mapping data(
3)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(36)
|
Alleles
and
phenotypes
|
All alleles(92) :
Targeted, knock-out(3)
Targeted, other(4)
Gene trapped(85)
| Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present. |
Phenotype Images (2)
|
|
Polymorphisms
|
SNPs within 2kb(665 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (30 records)
Data Summary:
Assays (10)
Results (215)
Tissues (123)
Images (115)
Theiler Stages: 1,2,3,5,20,21,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
5 |
|
42 |
| |
RT-PCR |
1 |
|
38 |
| |
In situ reporter (knock in) |
1 |
|
131 |
| |
RNA in situ |
1 |
|
2 |
| |
Immunohistochemistry |
2 |
|
2 |
cDNA source data(15)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(18)
cDNA(16)
Primer pair(1)
Other(1)
Antibodies(6)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:135482
Diehl JA et al.,
"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization."
Genes Dev 1998 Nov 15;12(22):3499-511
(Latest)
J:152211
Coulpier F et al.,
"Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers."
Glia 2009 Oct;57(13):1450-7
|
All references(117)
|
Other
accession IDs
|
MGI:1914056, MGI:1925394, MGI:2146721
|
