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| Nomenclature |
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Symbol:
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TWis
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Name:
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brachyury;
brachyury Wisconsin
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MGI ID: |
MGI:1857760 |
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Gene:
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T
Location:
Chr17:8627288-8635361 bp, + strand
Genetic Position: Chr17,
4.02 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Transposon insertion |
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Restriction mapping showed that this allele comprises a 5.5 kb early transposon-like insertion element. RT-PCR based analysis shows that at least 8 different mutant transcripts are produced from the TWis allele. These transcripts bypass the mutated exon 7 splice donor site and no wild type T transcripts are produced. (J:21263, J:107619) |
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Inheritance: |
Semidominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| Expression |
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:9032
Shedlovsky A et al.,
"Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus."
Proc Natl Acad Sci U S A 1988 Jan;85(1):180-4
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All: |
8 reference(s)
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