T<+> Allele Detail MGI Mouse (MGI:1857758)

T⁺
Allele Detail

Nomenclature

Symbol:	T⁺
Name:	brachyury; wild type
MGI ID:	MGI:1857758
Gene:	T Location: Chr17:8627288-8635361 bp, + strand Genetic Position: Chr17, 4.02 cM

Show the 1 image(s) involving this allele.

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:	Not Specified
Inheritance:	Not Specified

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any T Mutation:	45 strains or lines available

Expression

In Mice Carrying this Mutation:

13 assay results

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems

Genotypes:

behavior/neurological

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cardiovascular system

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embryogenesis

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endocrine/exocrine glands

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growth/size

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hearing/vestibular/ear

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homeostasis/metabolism

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lethality/postnatal

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lethality/prenatal-perinatal

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life span/aging

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limbs/digits/tail

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nervous system

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other phenotype

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reproductive system

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skeleton

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Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
ht1	T^Orl/T⁺	B6.Cg-T^Orl/EiJ
reproductive system primary sex reversal (J:71077) Background Sensitivity: on a B6 background, mice carrying this allele and a Y chromosome from AKR, LEWES/Ei, MA/MyJ, PL/J, RF/J, or the WSB/Ei inbred strain develop as infertile females on a B6 background, mice carrying this allele and a Y chromosome derived from BUB/BnJ, C57BL/6JEi, SJL/J, ST/bJ, or the SWR/J inbred strain develop as males
Genotype	Allelic Composition	Genetic Background
ht2	T^c-3H/T⁺	BALB/cOlaHsd
limbs/digits/tail absent tail (J:93195)
Genotype	Allelic Composition	Genetic Background
ht3	T^40H/T⁺	C57BL/6J
limbs/digits/tail short tail (J:93195)
Genotype	Allelic Composition	Genetic Background
ht4	T^41H/T⁺	C57BL/6J
limbs/digits/tail short tail (J:93195)
Genotype	Allelic Composition	Genetic Background
ht5	T^9J/T⁺	C57BL/6J
limbs/digits/tail short tail (J:72463) length varies from nearly normal to absent
Genotype	Allelic Composition	Genetic Background
ht6	T^8J/T⁺	C57BL/6J-Apoe^tm1Unc
limbs/digits/tail short tail (J:72464) length varies from nearly normal to absent
Genotype	Allelic Composition	Genetic Background
ht7	T^7J/T⁺	C57BL/6J-T^7J
limbs/digits/tail short tail (J:44446)
Genotype	Allelic Composition	Genetic Background
ht8	T^31H/T⁺	involves: 101/H * C3H/HeH * TFH
lethality/prenatal-perinatal perinatal lethality (J:62655) fewer than expected mice are born reproductive system reduced male fertility (J:62655) some males are infertile
Genotype	Allelic Composition	Genetic Background
ht9	T^33H/T⁺	involves: 101/H * C3H/HeH * TFH
lethality/prenatal-perinatal perinatal lethality (J:62655) fewer than expected mice are born reproductive system reduced male fertility (J:62655) some males are infertile
Genotype	Allelic Composition	Genetic Background
ht10	T^36H/T⁺	involves: 101/H * C3H/HeH * TFH
lethality/prenatal-perinatal perinatal lethality (J:62655) fewer than expected mice are born reproductive system reduced male fertility (J:62655) some males are infertile limbs/digits/tail short tail (J:62655) fewer than expected (27.1%) of mice are short-tailed
Genotype	Allelic Composition	Genetic Background
ht11	T^Wis/T⁺	involves: A/J
limbs/digits/tail absent tail (J:9032)
Genotype	Allelic Composition	Genetic Background
ht12	T^hp/T⁺	involves: AKR/J * C57BL/Gr * CBA/Gr
limbs/digits/tail polydactyly (J:31524) on the hind feet of embryos inheriting the T^hp allele from their mother abnormal tail development (J:31524) at E12 the base of the tail is constricted; the thickness of the tail itself varies at E13 the tail distal to the constriction is thinned by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment kinked tail (J:31524) varying degrees short tail (J:31524) shortened by varying amounts the only abnormality seen in older embryos thick tail (J:31524) degree of thickness varies reproductive system decreased litter size (J:31524) litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size other phenotype maternal effect (J:31524) heterozygous offspring from carrier females and normal males are edematous and die before or at birth homeostasis/metabolism edema (J:31524) embryos inheriting the T^hp allele from their mother are edematous growth/size postnatal slow weight gain (J:31524) characteristic of mice inheriting the T^hp allele from their father embryogenesis abnormal neural tube morphology/development (J:31524) at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother abnormal neural tube closure (J:31524) open neural tube (J:31524) characteristic of some E10 embryos inheriting the T^hp allele from their father spina bifida (J:31524) occurs at a low frequency among embryos inheriting the T^hp allele from their mother abnormal notochord morphology (J:31524) at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the T^hp allele from their father at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the T^hp allele from their father absent notochord (J:31524) at E10 the tail notochord may be absent in embryos inheriting the T^hp allele from their father cardiovascular system abnormal pericardium morphology (J:31524) inflation of the pericardium is seen in embryos inheriting the T^hp allele from their mother nervous system abnormal neural tube morphology/development (J:31524) at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother abnormal neural tube closure (J:31524) open neural tube (J:31524) characteristic of some E10 embryos inheriting the T^hp allele from their father spina bifida (J:31524) occurs at a low frequency among embryos inheriting the T^hp allele from their mother exencephaly (J:31524) occurs in low frequency among embryos inheriting the T^hp allele from their mother skeleton abnormal vertebral column (J:31524) may end abruptly before or at the level of the second sacral vertebra abnormal cervical vertebrae morphology (J:31524) characteristic of embryos inheriting the T^hp allele from their father one or more may be incomplete dorsally abnormal cervical atlas morphology (J:31524) characteristic of embryos inheriting the T^hp allele from their father frequently incomplete dorsally abnormal cervical axis morphology (J:31524) characteristic of embryos inheriting the T^hp allele from their father frequently incomplete dorsally abnormal sacral vertebrae morphology (J:31524) short vertebral column (J:31524)
Genotype	Allelic Composition	Genetic Background
ht13	T^39H/T⁺	involves: BALB/c * C3H/HeN
limbs/digits/tail abnormal tail morphology (J:63816)
Genotype	Allelic Composition	Genetic Background
ht14	T^29H/T⁺	involves: BALB/c * TFH
lethality/prenatal-perinatal perinatal lethality (J:62655) fewer than expected mice are born
Genotype	Allelic Composition	Genetic Background
ht15	T^Orl/T⁺	involves: C57BL/6J * Orl:Swiss
limbs/digits/tail abnormal tail morphology (J:15078) short tail (J:15078)
Genotype	Allelic Composition	Genetic Background
ht16	T^34H/T⁺	involves: STOCK T^34H * TFH
lethality/prenatal-perinatal perinatal lethality (J:62655) few heterozygotes mice of heterozygote females survive birth homeostasis/metabolism edema (J:62655) limbs/digits/tail short tail (J:62655)
Genotype	Allelic Composition	Genetic Background
ht17	T^c/T⁺	mixed
limbs/digits/tail abnormal tail bud morphology (J:106412) by E 12, mutants show constriction at the base of the tail later in development, the abnormalities observed are less severe and occur more posteriorly than in T^c/t^w5 embryos nervous system abnormal neural tube morphology/development (J:106412) at E12.5, one accessory neural tube is observed spina bifida occulta (J:106412) unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture abnormal spinal cord morphology (J:106412) embryos display ventral duplication of the spinal cord embryogenesis abnormal neural tube morphology/development (J:106412) at E12.5, one accessory neural tube is observed spina bifida occulta (J:106412) unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture split notochord (J:106412) some embryos show duplication or intermittent absence of the notochord skeleton spina bifida occulta (J:106412) unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture absent vertebrae (J:106412) embryos display partial or complete absence of bony vertebrae posterior to midliver level
Genotype	Allelic Composition	Genetic Background
ht18	T/T⁺	Not Specified
limbs/digits/tail abnormal tail development (J:15081) the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size decreased caudal vertebrae number (J:15081) caudal vertebrae numbers range from 10 to 24, with an average of 21 short tail (J:15081, J:13018) tail is reduced by about 1/3 in most mutants (J:15081) seen by E11 (J:13018) embryogenesis abnormal neural tube morphology/development (J:13018) neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal abnormal notochord morphology (J:13018, J:15081) contain a notochord, however it can be retained in the roof of the gut or cloaca for varying distances and for a limited period, it may be slow to separate from the overlying neural plate or neural tube, or it may secondarily become incorporated completely into the neural tube or the tail-gut (J:15081) the notocord has a central lumen in places (J:15081) commonly see branching of the notochord proper; at E10-12.5, branches occur mainly in the region of the cloaca and the proximal parts of the tail (J:15081) skeleton decreased caudal vertebrae number (J:15081) caudal vertebrae numbers range from 10 to 24, with an average of 21 decreased presacral vertebrae number (J:15081) nervous system abnormal neural tube morphology/development (J:13018) neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal
Genotype	Allelic Composition	Genetic Background
ht19	T^c/T⁺	Not Specified
limbs/digits/tail abnormal tail morphology (J:64262, J:5003) tail is reduced to a very short curly filament without skeleton and in some instances the tail is altogether absent (J:64262) while approximately 5% of heterozygotes have a short tail not more than 20% normal length, most have no normal tail but a short boneless caudal filament (J:5003) absent tail (J:64262, J:5003) short tail (J:64262, J:5003) skeleton rib fusion (J:5003) often extensive in the thoracic region short ribs (J:5003) abnormal nucleus pulposus morphology (J:5003) aside from slight traces in the lower thoracic and lumbar regions, the intervertebral nuclei pulposi are absent at 3 weeks of age abnormal cervical vertebrae morphology (J:5003) abnormal cervical atlas morphology (J:5003) the neural arch is partially double in some heterozygotes abnormal odontoid process (J:5003) the axis odontoid process is absent resulting in a horseshoe-shaped articulation between the atlas and axis cervical vertebral fusion (J:5003) between the second and third vertebrae decreased presacral vertebrae number (J:5003) abnormal vertebral arch development (J:5003) vertebral fusion (J:5003) thoracic vertebral fusion (J:5003) fusion of vertebral arches (J:5003) abnormal bone ossification (J:5003) the centra of cervical vertebrae are wider than normal, the axis tends to ossify from twin centers, and distortion and fusion is found in some throacic centra lethality/prenatal-perinatal neonatal lethality (J:5003) ratio of mutant to wild-type is less than 1 to 1 at birth lethality/postnatal postnatal lethality (J:5003) 32% of curtailed mice die between birth and weaning
Genotype	Allelic Composition	Genetic Background
ht20	T^h/T⁺	Not Specified
limbs/digits/tail short tail (J:13072) the tail of the original mouse was half normal length
Genotype	Allelic Composition	Genetic Background
ht21	T^Jic/T⁺	Not Specified
limbs/digits/tail short tail (J:14257)
Genotype	Allelic Composition	Genetic Background
cx22	T^34H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * STOCK T^34H * TFH
reproductive system transmission ratio distortion (J:62655) fewer than expected carried the T^34H allele
Genotype	Allelic Composition	Genetic Background
cx23	Nox3^het/Nox3^het T^31H/T⁺	involves: 101/H * C3H/HeH * TFH
behavior/neurological head tilt (J:62655) hearing/vestibular/ear head tilt (J:62655)
Genotype	Allelic Composition	Genetic Background
cx24	T^31H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system male infertility (J:62655)
Genotype	Allelic Composition	Genetic Background
cx25	Nox3^het/Nox3^het T^33H/T⁺	involves: 101/H * C3H/HeH * TFH
behavior/neurological head tilt (J:62655) hearing/vestibular/ear head tilt (J:62655)
Genotype	Allelic Composition	Genetic Background
cx26	T^30H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system male infertility (J:62655)
Genotype	Allelic Composition	Genetic Background
cx27	T^33H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) fewer than expected carried the T^33H allele reduced male fertility (J:62655) male fertility is low
Genotype	Allelic Composition	Genetic Background
cx28	Nox3^het/Nox3^het T^36H/T⁺	involves: 101/H * C3H/HeH * TFH
behavior/neurological head tilt (J:62655) hearing/vestibular/ear head tilt (J:62655)
Genotype	Allelic Composition	Genetic Background
cx29	T^36H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
lethality/postnatal postnatal lethality (J:62655) viability is poor and no males survive into adulthood
Genotype	Allelic Composition	Genetic Background
cx30	T^32H/T⁺ t^h51/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) fewer than expected offsprings carried the t^h51 allele
Genotype	Allelic Composition	Genetic Background
cx31	T^32H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) fewer than expected carried the T^32H allele
Genotype	Allelic Composition	Genetic Background
cx32	T^30H/T⁺ t⁶/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) the transmission ratio distortion associated with t⁶ is increased
Genotype	Allelic Composition	Genetic Background
cx33	T^32H/T⁺ t⁶/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) the transmission ratio distortion associated with t⁶ is increased
Genotype	Allelic Composition	Genetic Background
cx34	T^36H/T⁺ t⁶/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system transmission ratio distortion (J:62655) the transmission ratio distortion associated with t⁶ is increased
Genotype	Allelic Composition	Genetic Background
cx35	T^22H/T⁺ t^w32/t⁺	involves: 101/H * C3H/HeH * TFH
reproductive system male infertility (J:62655)
Genotype	Allelic Composition	Genetic Background
cx36	Igf2r^tm2Wag/Igf2r⁺ T^hp/T⁺	involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6
lethality/prenatal-perinatal prenatal lethality (J:68721) when the allele is inherited paternally, fewer than expected mice are born however, unlike when only T^hp is inherited maternally, some mice are recovered at birth life span/aging decreased survivor rate (J:68721) when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, some mice survive birth and reach maturity despite some prenatal lethality limbs/digits/tail abnormal tail morphology (J:68721) when is Igf2r^tm2Wag inherited paternally and T^hp is maternally, mice have a bent tail compared to wild-type mice reproductive system reproductive system phenotype (J:68721) when the allele is inherited paternally, mice are fertile
Genotype	Allelic Composition	Genetic Background
cx37	Sp5^tm1Rbe/Sp5^tm1Rbe T/T⁺	involves: 129P2/Ola * C57BL/6J
limbs/digits/tail decreased caudal vertebrae number (J:65743) majority of tails are comprised of fewer than 8 vertebrae short tail (J:65743) skeleton abnormal vertebrae morphology (J:65743) decreased caudal vertebrae number (J:65743) majority of tails are comprised of fewer than 8 vertebrae abnormal lumbar vertebrae morphology (J:65743) lumbar vertebrae defect consisting of an imperfect fusion of the two ventral halves of the vertebra, resulting in an abnormal centrum
Genotype	Allelic Composition	Genetic Background
cx38	D17Aus9^df13J/D17Aus9⁺ T^7J/T⁺	involves: 129S4/SvJae * BALB/cJ * C57BL/6
growth/size decreased body size (J:81651) mice are smaller than wild-type mice
Genotype	Allelic Composition	Genetic Background
cx39	D17Aus9^df12J/D17Aus9⁺ T^7J/T⁺	involves: 129S4/SvJae * BALB/cJ * C57BL/6
lethality/prenatal-perinatal embryonic lethality during organogenesis (J:81651) embryos are absorbed by E10.5 embryogenesis failure of initiation of embryo turning (J:81651) mice do not undergo turning absent notochord (J:81651) no discernible notochord is observed embryonic growth arrest (J:81651) development is arrested at E9.5 with only 3 to 4 somites developed
Genotype	Allelic Composition	Genetic Background
cx40	D17Aus9^df10J/D17Aus9⁺ T^7J/T⁺	involves: 129S4/SvJae * BALB/cJ * C57BL/6
lethality/prenatal-perinatal embryonic lethality during organogenesis (J:81651) embryos are absorbed by E10.5 embryogenesis failure of initiation of embryo turning (J:81651) mice do not undergo turning absent notochord (J:81651) no discernible notochord is observed embryonic growth arrest (J:81651) development is arrested at E9.5 with only 3 to 4 somites developed
Genotype	Allelic Composition	Genetic Background
cx41	Map3k4^byg/Map3k4⁺ T^hp/T⁺	involves: AKR/J * C3H/HeH * C57BL/6J
reproductive system abnormal testis cord formation (J:153050) testes exhibit regions lacking clear cord morphology unlike in wild-type mice primary sex reversal (J:153050) at E13.5 and E14.5, XY gonads exhibit disruption in cord morphology or gonadal sex reversal nervous system abnormal neural tube morphology/development (J:153050) endocrine/exocrine glands abnormal testis cord formation (J:153050) testes exhibit regions lacking clear cord morphology unlike in wild-type mice embryogenesis abnormal neural tube morphology/development (J:153050)
Genotype	Allelic Composition	Genetic Background
cx42	T^29H/T⁺ t^w32/t⁺	involves: BALB/c * TFH
reproductive system transmission ratio distortion (J:62655) no offsprings carried the T^29H allele
Genotype	Allelic Composition	Genetic Background
cx43	T^29H/T⁺ t⁶/t⁺	involves: BALB/c * TFH
reproductive system transmission ratio distortion (J:62655) the transmission ratio distortion associated with t⁶ is increased
Genotype	Allelic Composition	Genetic Background
cx44	T^Orl/T⁺ Qk^qk/Qk⁺	involves: C57BL/6J * Orl:Swiss
behavior/neurological abnormal motor capabilities/coordination/movement (J:15078) abnormal involuntary movement (J:15078) tremors (J:15078) mice heterozygous for T and Qk display tremors characteristic of the recessive mutation QK, demonstrating that T comprises a deletion limbs/digits/tail abnormal tail morphology (J:15078) short tail (J:15078)
Genotype	Allelic Composition	Genetic Background