Plau<tm1Mlg> Targeted Allele Detail MGI Mouse (MGI:1857289)

Plau^tm1Mlg
Targeted Allele Detail

Nomenclature

Symbol:	Plau^tm1Mlg
Name:	plasminogen activator, urokinase; targeted mutation 1, Richard C Mulligan
MGI ID:	MGI:1857289
Synonyms:	u-PA^-, UPA-
Gene:	Plau Location: Chr14:21655929-21662610 bp, + strand Genetic Position: Chr14, 2.5 cM

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:17427
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:	Targeted (knock-out)
Mutations:	Insertion, Intragenic deletion
	The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encompassing all but 23 amino acids of the coding sequence. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Plau Mutation:	3 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2	hm3	cx4	cx5	cx6	tg7
cardiovascular system				√	√			N
cardiovascular system phenotype								N
increased resistance to induced choroidal neovascularization				√
heart left ventricle hypertrophy				√
cardiac interstitial fibrosis				√
increased ventricle muscle contractility				√
aortic elastic tissue lesions					√
decreased susceptibility to atherosclerosis					√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
cellular							√
necrosis							√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
craniofacial				√			√
abnormal outer ear morphology				√			√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
digestive/alimentary system		√		√			√
abnormal rectum morphology		√
rectal prolapse		√		√			√
abnormal perineum morphology		√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
endocrine/exocrine glands		√
herniated seminal vesicle		√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
growth/size				N			√
growth/size phenotype				N
decreased body size							√
decreased body weight							√
cachexia							√
postnatal growth retardation							√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
hearing/vestibular/ear				√			√
abnormal outer ear morphology				√			√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
hematopoietic system		√		√
hematopoietic system phenotype				N
decreased T cell proliferation		√
increased lymphocyte cell number				√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
homeostasis/metabolism		√	√	√			√
abnormal fibrinogen physiology		√		√
abnormal cytokine level		√
reduced thrombolysis			√				√
abnormal circulating protein level				√
thrombosis				√			√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
immune system		√		√
abnormal fibrinogen physiology		√		√
abnormal cytokine level		√
decreased susceptibility to induced arthritis		√
decreased inflammatory response		√
increased lymphocyte cell number				√
abnormal cell-mediated immunity				√
decreased T cell proliferation		√
abnormal macrophage physiology				√
impaired macrophage recruitment		√		√
abnormal neutrophil physiology				√
impaired neutrophil phagocytosis				√
impaired granulocyte bactericidal activity				√
increased susceptibility to fungal infection				√
increased susceptibility to parasitic infection				√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
lethality/prenatal-perinatal						√
embryonic lethality						√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
life span/aging				N			√
life span/aging phenotype				N
premature death							√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
muscle		√		√
abnormal muscle regeneration		√
myopathy		√
increased ventricle muscle contractility				√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
nervous system				N
nervous system phenotype				N
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
other phenotype				N
other phenotype phenotype				N
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
reproductive system		√		N			√
reproductive system phenotype				N
abnormal perineum morphology		√
herniated seminal vesicle		√
decreased litter size							√
reduced fertility							√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
respiratory system				√			√
pulmonary interstitial fibrosis				√
respiratory distress							√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
skeleton		√
decreased susceptibility to induced arthritis		√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
tumorigenesis		√						√
decreased metastatic potential		√
altered tumor morphology		√
decreased tumor growth/size		√
carcinoma								√
		hm1	hm2	hm3	cx4	cx5	cx6	tg7
vision/eye				√			√
increased resistance to induced choroidal neovascularization				√
abnormal eyelid morphology				√			√

		hm1	hm2	hm3	cx4	cx5	cx6	tg7
Disease Models				√
Alzheimer Disease; AD				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

hm1

Plau^tm1Mlg/Plau^tm1Mlg

B6.Cg-Plau^tm1Mlg

hm2

Plau^tm1Mlg/Plau^tm1Mlg

either: B6.Cg-Plau^tm1Mlg or (involves: Black Swiss * C57BL/6)

hm3 Disease Model

Plau^tm1Mlg/Plau^tm1Mlg

involves: 129S2/SvPas * C57BL/6

cx4

Apoe^tm1Bres/Apoe^tm1Bres
Plau^tm1Mlg/Plau^tm1Mlg

involves: 129 * C57BL/6

cx5

Plau^tm1Mlg/Plau^tm1Mlg
Thbd^tm2Rdr/Thbd^tm2Rdr

involves: 129S2/SvPas

cx6

Plat^tm1Mlg/Plat^tm1Mlg
Plau^tm1Mlg/Plau^tm1Mlg

involves: 129S2/SvPas * C57BL/6

tg7

Plau^tm1Mlg/Plau^tm1Mlg
Tg(RIP1-Tag)2Dh/0

involves: C57BL/6

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
			Allelic Composition	Genetic Background
Models with phenotypic similarity to human diseases associated with human PLAU.
Alzheimer Disease; AD OMIM ID: 104300		hm3	Plau^tm1Mlg/Plau^tm1Mlg	involves: 129S2/SvPas * C57BL/6	J:104962

References

Original:	J:17427 Carmeliet P et al., "Physiological consequences of loss of plasminogen activator gene function in mice." Nature 1994 Mar 31;368(6470):419-24
All:	75 reference(s)

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