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| Nomenclature |
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Symbol:
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Cyp7a1tm1Rus
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Name:
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cytochrome P450, family 7, subfamily a, polypeptide 1;
targeted mutation 1, David W Russell
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MGI ID: |
MGI:1857285 |
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Synonyms: |
Cyp7-, CYP7A1- |
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Gene:
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Cyp7a1
Location:
Chr4:6192759-6202780 bp, - strand
Genetic Position: Chr4,
Syntenic
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Oily coat phenotype of Cyp7a1tm1Rus/Cyp7a1tm1Rus nursing mothers and pups
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:34342
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt1+
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A genomic fragment containing part of exon 3, exon 4 and exon 5 was replaced with a neomycin selection cassette. Activity assays on extracts of liver microsomal memebrane preparations derived from homozygous mice demonstrated that no functional protein is made from this allele. (J:34342) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:34342
Ishibashi S et al.,
"Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation."
J Biol Chem 1996 Jul 26;271(30):18017-23
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All: |
13 reference(s)
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