Trp53<tm1Tyj> Targeted Allele Detail MGI Mouse (MGI:1857263)

Trp53^tm1Tyj
Targeted Allele Detail

Nomenclature

Symbol:	Trp53^tm1Tyj
Name:	transformation related protein 53; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:1857263
Synonyms:	p53-, p53^delta, p53^null, Trp53-, Trp53^KO
Gene:	Trp53 Location: Chr11:69393861-69405375 bp, + strand Genetic Position: Chr11, 39.0 cM, cytoband B2-C

Persistent hyperplastic primary vitreous (PHPV) in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice is p53 independent

Show the 1 image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:17728
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:	Targeted (knock-out)
Mutations:	Insertion, Intragenic deletion
	A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6. (J:17728)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	125 strains or lines available

Expression

In Mice Carrying this Mutation:

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

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Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found