Rag1<tm1Mom> Targeted Allele Detail MGI Mouse (MGI:1857241)

Rag1^tm1Mom
Targeted Allele Detail

Nomenclature

Symbol:	Rag1^tm1Mom
Name:	recombination activating gene 1; targeted mutation 1, Peter Mombaerts
MGI ID:	MGI:1857241
Synonyms:	Rag-, RAG-1-, Rag-1KO, Rag1-, RAG1^null
Gene:	Rag1 Location: Chr2:101478439-101489658 bp, - strand Genetic Position: Chr2, 56.0 cM

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:1934
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:	Targeted (knock-out)
Mutations:	Insertion, Intragenic deletion
	A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. (J:1934, J:96036)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 20 strains available Cell Lines: 0 lines available
Carrying any Rag1 Mutation:	28 strains or lines available

Expression

In Mice Carrying this Mutation:

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found