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| Nomenclature |
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Symbol:
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Prkcctm1Stl
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Name:
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protein kinase C, gamma;
targeted mutation 1, Susumu Tonegawa
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MGI ID: |
MGI:1857237 |
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Synonyms: |
PKCgamma-KO |
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Gene:
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Prkcc
Location:
Chr7:3303916-3331005 bp, + strand
Genetic Position: Chr7,
2.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:16392
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A neomycin resistance cassette replaced 2.5kb of sequence containing the exon that encodes the nucleotide binding domain. Northern blot analysis of total brain RNA demonstrated that homozygous mutant mice lack normal transcripts. Western blot analysis of total brain protein did not detect the protein in homozygous mutant mice. (J:16392) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:16392
Abeliovich A et al.,
"Modified hippocampal long-term potentiation in PKC gamma-mutant mice."
Cell 1993 Dec 31;75(7):1253-62
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All: |
25 reference(s)
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