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Nos2tm1Lau
Targeted Allele Detail

Nomenclature
Symbol: Nos2tm1Lau
Name: nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach
MGI ID: MGI:1857228
Synonyms: iNOS KO, iNOS-, NOS2-, NOS2tm/Lau, Nos2tm1Lau
Gene: Nos2   Location: Chr11:78734289-78773756 bp, + strand    Genetic Position: Chr11, 45.6 cM
Mutation
origin
Germline Transmission: Earliest citation of germline transmission: J:29677
Parent Cell Line: E14TG2a (ES Cell)
Strain of Origin: 129P2/OlaHsd
Mutation
description
Allele Type: Targeted (knock-out)
Mutations: Insertion, Intragenic deletion
  A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. (J:29677)
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation: 8 strains or lines available
Phenotype
summary
help icon
Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
hm1
 
hm2
 
hm3
 
hm4
 
hm5
 
hm6
 
cx7
 
cx8
 
cx9
 
cx10
 
tg11
 
tg12
 
tg13
 
tg14
 
tg15
  
adipose tissue          		    √          
  
behavior/neurological          		√√          √  
  
cardiovascular system          		√   √        √ 
  
digestive/alimentary system          		√              
  
endocrine/exocrine glands          		    √          
  
hematopoietic system          		√   √          
  
homeostasis/metabolism          		√ √ √√         
  
immune system          		√√ N√          
  
lethality/prenatal-perinatal          		      √  √     
  
life span/aging          		√   √          
  
muscle          		√              
  
nervous system          		√√          √ √
  
other phenotype          		            √ √
  
renal/urinary system          		     √         
  
reproductive system          		    √          
  
respiratory system          		√√             
  
skeleton          		√              
  
skin/coat/nails          		    √          
  
tumorigenesis          		    √  √√ √√   
  
vision/eye          		√              
 
  
Disease Models          		            √  
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 hm1   		 Nos2tm1Lau/Nos2tm1Lau B6.129P2-Nos2tm1Lau
  
 hm2   		 Nos2tm1Lau/Nos2tm1Lau B6.129P2-Nos2tm1Lau/J
  
 hm3   		 Nos2tm1Lau/Nos2tm1Lau B6;129P2-Nos2tm1Lau/J
  
 hm4   		 Nos2tm1Lau/Nos2tm1Lau involves: 129P2/OlaHsd
  
 hm5   		 Nos2tm1Lau/Nos2tm1Lau involves: 129P2/OlaHsd * C57BL/6
  
 hm6   		 Nos2tm1Lau/Nos2tm1Lau involves: 129P2/OlaHsd * C57BL/6J
  
 cx7   		 Nos2tm1Lau/Nos2tm1Lau
Nos3tm1Unc/Nos3tm1Unc		 B6.129P2-Nos3tm1Unc Nos2tm1Lau
  
 cx8   		 ApcMin/Apc+
Nos2tm1Lau/Nos2tm1Lau		 B6.Cg-Nos2tm1Lau ApcMin
  
 cx9   		 ApcMin/Apc+
Nos2tm1Lau/Nos2+		 B6.Cg-Nos2tm1Lau ApcMin
  
 cx10   		 Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Lau/Nos2tm1Lau		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
  
 tg11   		 Nos2tm1Lau/Nos2tm1Lau
Tg(MMTV-PyVT)634Mul/0		 B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul
  
 tg12   		 Nos2tm1Lau/Nos2tm1Lau
Tg(MMTV-PyVT)634Mul/0		 FVB.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul
  
 tg13   Disease Model  		 Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0		 involves: 129P2/OlaHsd * C57BL/6 * SJL
  
 tg14   		 Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0		 involves: 129P2/OlaHsd * C57BL/6J
  
 tg15   		 Nos2tm1Lau/Nos2tm1Lau
Tg(Thy1-APPSwDutIowa)BWevn/?		 involves: C57BL/6
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models with phenotypic similarity to human diseases not associated with human NOS2.
Alzheimer Disease; AD
OMIM ID: 104300		  
 
tg13		Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0		involves: 129P2/OlaHsd * C57BL/6 * SJLJ:112919
Models involving transgenes or other mutation types.1
Alzheimer Disease; AD
OMIM ID: 104300		  
 
tg13		Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0		involves: 129P2/OlaHsd * C57BL/6 * SJLJ:112919
1Models involving transgenes or other mutation types may also appear in other sections of the table.
References
Original: J:29677 Laubach VE et al., "Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death." Proc Natl Acad Sci U S A 1995 Nov 7;92(23):10688-92
All: 244 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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11/20/2009
MGI_4.31
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