Ngfr<tm1Jae> Targeted Allele Detail MGI Mouse (MGI:1857226)

Ngfr^tm1Jae
Targeted Allele Detail

Nomenclature

Symbol:	Ngfr^tm1Jae
Name:	nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:1857226
Synonyms:	Ngfr^-, NGFR^tm1Jac, p75(III)^-, p75-, p75-KO, p75^exonIII-, p75^NGFR, p75^NTR-, p75^NTRexon3-null, p75e3-, p75NTR-
Gene:	Ngfr Location: Chr11:95430132-95449049 bp, - strand Genetic Position: Chr11, 55.6 cM

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:43748
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:	Targeted (knock-out)
Mutation:	Insertion
	A neomycin selection cassette was inserted into the third exon of the gene, disrupting the sequences encoding cysteine repeats 2, 3, and 4. Northern blot analysis revealed that the mutant gene did not yield a full length mRNA, however subsequent RT-PCR analysis, described in J:71955, detected an endogenous alternative transcript which lacks exon 3. Western blot analysis showed that the full length isoform was absent in homozygous mutant mice, but an isoform lacking cysteine repeats 2, 3, and 4 was present in both wild and mutant mice. In vitro experiments showed the persisting isoform to be a transmembrane protein that cannot bind neurotrophins but interacts with tyrosine kinase receptors. (J:43748, J:71955)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Ngfr Mutation:	7 strains or lines available

Expression

In Mice Carrying this Mutation:

21 assay results

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems

Genotypes:

behavior/neurological

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cardiovascular system

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craniofacial

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digestive/alimentary system

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growth/size

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hearing/vestibular/ear

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hematopoietic system

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homeostasis/metabolism

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immune system

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lethality/postnatal

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lethality/prenatal-perinatal

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life span/aging

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limbs/digits/tail

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liver/biliary system

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muscle

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nervous system

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renal/urinary system

respiratory system

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skin/coat/nails

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taste/olfaction

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vision/eye

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Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	Ngfr^tm1Jae/Ngfr^tm1Jae	B6.129S4-Ngfr^tm1Jae
nervous system abnormal muscle innervation (J:90280) areas of the epithelium of the tongue lack innervation and the filiform papillae are sparsely innervated the axons in the tongue display reduced branching and smaller terminal arbors abnormal neurogenesis (J:127639) peripheral nerves in the hindlimb, forelimb, and trigeminal ganglia are severely stunted compared to in wild-type mice abnormal axon outgrowth (J:127639) growth cones from dorsal root ganglion neurons are more sensitive to Sema3A repulsion than wild-type neurons when treated with 15 pM Sema3A outgrowth rate inhibition is increased (15 um per hour compared to 35 um per hour for wild-type neurons) however, increased sensitivity to Sema3A repulsion is alleviated in a double heterozygote cross of Ngfr and Sema3A abnormal neuron morphology (J:128451) like wild-type neurons, cultured superior cervical ganglion neurons are resistant to apoptosis induced by pro-NGF and pro-BDNF the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice at 60 weeks sympathetic neuron cell bodies are 25% smaller than in wild-type mice unlike in wild-type mice, superior cervical ganglion are protected from age-related apoptosis abnormal sensory neuron innervation (J:90280) innervation of the somatosensory prominences is reduced innervation of the fungiform papillae are reduced at P0 there are 35% fewer geniculate ganglion neurons that supply taste neurons to the fungiform papillae in homozygotes compared to wild-type mice increased neuron number (J:128451) the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice increased retinal photoreceptor cell number (J:115542) after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice abnormal gustatory papillae taste buds (J:90280) at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice homozygous mice have fewer fungiform taste buds than wild-type mice digestive/alimentary system abnormal tongue epithelium morphology (J:90280) at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions abnormal circumvallate papillae (J:90280) the vallate papilla is deformed and small in neonatal mutants at P7 the vallate trench is only 60% as deep as in wild-type mice cardiovascular system abnormal blood vessel healing (J:109753) formation of neointimal lesions is enhanced 2 and 4 weeks after ligation compared to in wild-type mice such that there is a 2- to 4-fold increase in intimal to medial ratio at 500 um and 1.0 mm proximal to the ligation apoptosis in neointimal lesions is decreased by 60% to 70% however, infiltration of inflammatory cells is normal taste/olfaction abnormal gustatory papillae taste buds (J:90280) at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice homozygous mice have fewer fungiform taste buds than wild-type mice immune system abnormal Kupffer cell morphology (J:120368) after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice increased susceptibility to experimental autoimmune encephalomyelitis (J:112769) mice have an increased risk of developing severe experimental autoimmune encephalomyelitis compared to wild-type mice B220+ B cells make up 6% of cells in the inflammatory cuffs compared to 15% in wild-type mice immunized with MOG35-55 the population of Iba-1+ cells in the inflammatory cuffs is reduced by 10% compared to in wild-type mice immunized with MOG35-55 polymorphonuclear cells are reduced by half compared to in wild-type mice immunized with MOG35-55 microglial/macrophage and neutrophil numbers in the inflammatory infiltrate are reduced 68% to 40% while the size of the inflitratory cuffs is normal or even larger than in wild-type mice mice display considerable infiltration of fibronectin into the spinal cord parenchyma however, the number of double-positive (monocyte) cells is normal homeostasis/metabolism abnormal blood vessel healing (J:109753) formation of neointimal lesions is enhanced 2 and 4 weeks after ligation compared to in wild-type mice such that there is a 2- to 4-fold increase in intimal to medial ratio at 500 um and 1.0 mm proximal to the ligation apoptosis in neointimal lesions is decreased by 60% to 70% however, infiltration of inflammatory cells is normal liver/biliary system abnormal Kupffer cell morphology (J:120368) after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice vision/eye increased retinal photoreceptor cell number (J:115542) after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice hematopoietic system abnormal Kupffer cell morphology (J:120368) after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice
Genotype	Allelic Composition	Genetic Background
hm2	Ngfr^tm1Jae/Ngfr^tm1Jae	B6.129S4-Ngfr^tm1Jae/J
hearing/vestibular/ear cochlear hair cell degeneration (J:110434) by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs organ of Corti degeneration (J:110434) at 1 month of age, male homozygotes exhibit a grossly normal organ of the Corti, except for a slight reduction in the number of SGNs by 6 months, male homozygotes show complete degeneration of the organ of Corti in the basal turns decreased brainstem auditory evoked potential (J:110434) at 4 months of age, male homozygotes exhibit a significant elevation (>33 dB SPL) in click-evoked ABR thresholds relative to wild-type males at 6 months and 1 year, male homozygotes continue to display significant increases in ABR thresholds relative to age-matched wild-type males (100 and 126 dB SPL, respectively) however, no significant differences in click-evoked ABR thresholds are observed at 1 month, consistent with a normal cochlear structure at this age increased susceptibility to age-related hearing loss (J:110434) starting at 4 months, male homozygotes display an age-related progressive hearing loss relative to age-matched wild-type males by 1 year of age, homozygotes are unresponsive to click stimuli at the maximum level (136 dB SPL) sensorineural hearing loss (J:110434) male homozygotes show progressive hearing loss at 4 months, when both SGN degeneration and hair cell loss are observed in the basal cochlear turn nervous system cochlear hair cell degeneration (J:110434) by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs cochlear ganglion degeneration (J:110434) starting at 1 month, male homozygotes show a slight (15.7%) but progressive loss of SGNs from the basal to the apical cochlear turns at 4 months, male homozygotes display significant SGN degeneration in the basal cochlear turn and swelling of the afferent dendrites below IHCs in the middle turns by 6 months, the density of SGNs is significantly reduced in the middle and basal turns, with a 59.8% loss of SGNs in the most basal turns
Genotype	Allelic Composition	Genetic Background
hm3	Ngfr^tm1Jae/Ngfr^tm1Jae	C;129S-Ngfr^tm1Jae/J
nervous system abnormal neuron apoptosis (J:46125) reduced levels of neuronal cell death
Genotype	Allelic Composition	Genetic Background
hm4	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129 * BALB/c
nervous system abnormal axon outgrowth (J:96121) reduced inhibition by myelin of neurite outgrowth from dorsal root ganglion neurons, but not cerebellar neurons, compared to heterozygous controls, indicating that mutant neurons are much less sensitive to myelin reduced inhibition by Nogo-66 (Rtn4) peptide of neurite outgrowth from P7 cerebellar neurons compared with heterozygous controls, however homozygotes did not show enhanced regeneration of corticospinal tract axons in comparison with wild-type after spinal dorsal hemisection
Genotype	Allelic Composition	Genetic Background
hm5	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S1/Sv * 129S4/SvJae
nervous system abnormal superior colliculus (J:145459) the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice abnormal retinal ganglion cell morphology (J:145459) the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice vision/eye abnormal retinal ganglion cell morphology (J:145459) the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
Genotype	Allelic Composition	Genetic Background
hm6	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae
nervous system abnormal cholinergic neuron morphology (J:62379) increased size of cholinergic forebrain neurons abnormal superior colliculus (J:145459) the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice however, total area of the superior colliculus is normal abnormal sensory neuron innervation (J:43749) absence of sensory innervation to pineal and sweat glands abnormal axon guidance (J:145459) when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons however, avoidance of stripes with EPHA5-Fc is normal decreased neuron apoptosis (J:123022) at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice nearly all neurons cultured with NT4 survive unlike wild-type neurons abnormal retinal ganglion cell morphology (J:145459) 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice behavior/neurological abnormal spatial learning (J:62379) spatial learning is improved compared to in wild-type mice without deterioration with age vision/eye abnormal retinal ganglion cell morphology (J:145459) 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
Genotype	Allelic Composition	Genetic Background
hm7	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * BALB/c
nervous system decreased muscle spindle number (J:53825) spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice abnormal sensory neuron innervation (J:43748, J:42087) the dermis of fore- and hindlimb paws either lacks or have reduced numbers of Pde6a+ sensory fibers and small-diameter nerves are absent (J:43748) only a few single fibers are present in the subepidermis and none are detected in the epidermis of fore- and hindlimb paws (J:43748) reduced innervation is not restricted to hairless patches (J:43748) at 3 to 5 months, Pde6a+ pulpal neurons are decreased (J:42087) however, sympathetic innervation of the iris and salivary glands is normal (J:43748) abnormal dorsal root ganglion morphology (J:53825) mice exhibit a loss of myelinated fibers in the dorsal root ganglion abnormal proprioceptive neuron morphology (J:53825) mice exhibit a 50% loss of proprioreceptive neurons in L4 of the dorsal root ganglion small L4 dorsal root ganglion (J:53825) at E14.5, L4 is smaller than in wild-type mice due to a 7.5-fold increase in apoptosis muscle abnormal muscle morphology (J:53825) muscles exhibit fewer myelinated fibers than in wild-type mice (36+/-2 compared to 76+/-2 in wild-type mice) decreased muscle spindle number (J:53825) spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice behavior/neurological abnormal sensory capabilities/reflexes/nociception (J:43748) prolonged latency in hot plate test homeostasis/metabolism extremity edema (J:43748) at 4 months of age, mice exbihit edema in the fore- and hindlimb paws limbs/digits/tail ulcerated paws (J:43748) at 4 months of age, fore- and hindlimb paws become edematous and develop severe ulcers ulcers progress more proximally ulcers are complicated by secondary infections that result in the lose of toenails and hair epidermis and epidermal structures are lost from areas affected by ulcers excessive epidermal proliferation is present at the edges of ulcers renal/urinary system renal/urinary system phenotype (J:43748) unlike in studies using p75^NGFR oligonucleotide knockdown, kidney function is normal skin/coat/nails abnormal hair follicle structure/orientation (J:43748) loss of follicles, at distal extremities, progressive to more proximal regions craniofacial abnormal mouth morphology (J:42087) the height of the oral cavity is reduced abnormal tooth morphology (J:42087) increased signs of wear on molars abnormal molar morphology (J:42087) mandibular molar occlusal facets are longer than in wild-type mice abnormal molar crown morphology (J:42087) maxillary molar crown height is reduced by 15% however, full height of teeth is normal
Genotype	Allelic Composition	Genetic Background
hm8	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * C57BL/6
nervous system abnormal axon outgrowth (J:139381) axons of mutant neurons grown in vitro in the presence of NGF grow equally well regardless if they are stimulated or not in contrast to wild-type neurons where stimulated axons out compete non-stimulated axons this lack of growth disadvantage in non-stimulated axons is due to less axon degeneration than occurs to wild-type neurons abnormal axon pruning (J:139381) sympathetic neurons of the superior cervical ganglion (SCG) have improper pruning of axons from neurons that reach into both eye compartments SCG neurons in wild-type mice reduce through axon pruning the number of neurons projecting to both eyes from 78% at p20 to 20% at p50 mutant mice have a similar percentage of SCG neurons that connect to both eyes at P20 but this percentage does not decrease with age at p35 where SCG neurons are actively pruning exons in wild-type mice, mutant mice have significantly less degenerating SCG axons than in wild-type mice
Genotype	Allelic Composition	Genetic Background
hm9	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * C57BL/6J
nervous system decreased motor neuron number (J:116954) the number of motor neurons in tibial nerve is reduced abnormal peripheral nervous system regeneration (J:116954) motor axonal regeneration is increased in the tibial nerve cross-suture
Genotype	Allelic Composition	Genetic Background
ht10	Ngfr^tm1Jae/Ngfr⁺	B6.129S4-Ngfr^tm1Jae
nervous system abnormal neurogenesis (J:127639) nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfr^tm1Jae homozygotes abnormal axon outgrowth (J:127639) neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfr^tm1Jae homozygotes respiratory system decreased airway responsiveness (J:115419) unlike in wild-type mice, no airway hyper-responsiveness was observed following exposure to Ach and ovalbumin (50% brionchiorestriction occurs at 580 ug per kg for Ach and 586 ug per kg ovalbulmin compared to 552 ug per kg Ach and 62.5 ug per kg ovalbumin for wild-type mice) total leukocytes, eosinophils and lymphocytes do not increase as in wild-type following exposure to provocation agent unlike in exposed wild-type mice, no pulmonary eosinophilic inflammation is observed unlike in exposed wild-type mice IL-4 and IL-5 production is not increased while IgE levels increase following exposure to provocation they do not increase as much as in wild-type mice however, interferon-gamma production following exposure to provocation agent is normal
Genotype	Allelic Composition	Genetic Background
cx11	Ngfr^tm1Jae/Ngfr^tm1Jae Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
life span/aging premature death (J:120368) median survival is 2.5 months liver/biliary system abnormal hepatocyte morphology (J:120368) the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice) increased hepatocyte apoptosis (J:120368) mice exhibit apoptosis in the liver that is restricted to hepatocytes hepatic necrosis (J:120368) mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions growth/size decreased body size (J:120368) at 5 weeks of age
Genotype	Allelic Composition	Genetic Background
cx12	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae
nervous system decreased neuron apoptosis (J:123022) at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice
Genotype	Allelic Composition	Genetic Background
cx13	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3⁺	involves: 129S4/SvJae * BALB/c
lethality/postnatal postnatal lethality (J:53825) few mice survive passed 3 weeks of age nervous system decreased muscle spindle number (J:53825) spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice absent muscle spindles (J:53825) 31% of soleus muscles are devoid of muscle spindles decreased sensory neuron number (J:53825) mice exhibit a 78% loss in sensory neurons in the dorsal root ganglion abnormal dorsal root ganglion morphology (J:53825) mice exhibit a loss of 82% myelinated fibers in the dorsal root ganglion mice exhibit a loss of 75% of dorsal root ganglion neurons abnormal proprioceptive neuron morphology (J:53825) at E14.5, Ia neuron projections in the dorsal root ganglion are severely reduced mice exhibit a 90% loss of proprioreceptive neurons in the dorsal root ganglion small L4 dorsal root ganglion (J:53825) at E14.5, L4 is smaller than in wild-type mice due to a 12.1-fold increase in apoptosis behavior/neurological ataxia (J:53825) mice exhibit ataxia during the first two weeks after birth but not during adulthood dystonia (J:53825) mice exhibit dystonia during the first two weeks after birth but not during adulthood abnormal gait (J:53825) mice exhibit an unstable gait and mild posturing of extremities during the first two weeks after birth but not during adulthood muscle dystonia (J:53825) mice exhibit dystonia during the first two weeks after birth but not during adulthood abnormal muscle morphology (J:53825) muscles exhibit fewer myelinated fibers than in wild-type mice (26+/-2 compared to 76+/-2 in wild-type mice) decreased muscle spindle number (J:53825) spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice absent muscle spindles (J:53825) 31% of soleus muscles are devoid of muscle spindles muscle spasm (J:53825) mice that survive longer than 3 weeks exhibit flexor spasms and uplifting of hindlimbs during weeks 3 to 4 growth/size decreased body weight (J:53825) mice weight 10% to 30% less than wild-type mice
Genotype	Allelic Composition	Genetic Background
cx14	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3^tm1Jae	involves: 129S4/SvJae * BALB/c
lethality/prenatal-perinatal neonatal lethality (J:53825) mice die at birth
Genotype	Allelic Composition	Genetic Background
cx15	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a⁺	involves: 129S4/SvJae * C57BL/6
nervous system nervous system phenotype (J:127639) at E12.5, mice exhibit normal neuron growth that is increased 3-fold in hindlimbs, 2.7-fold in forelimbs and 4.4-fold in trigeminal ganglion compared to Ngfr^tm1Jae homozygotes
Genotype	Allelic Composition	Genetic Background
cx16	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a^tm1Mcf	involves: 129S4/SvJae * C57BL/6
nervous system abnormal neurogenesis (J:127639) peripheral axons overshot the front observed in wild-type mice axon density is increased 2.28-fold in hindlimbs and 1.71-fold in forelimbs compared to in wild-type mice but not as much as in Sema3a^tm1Mcf homozygotes (5.97-fold in hindlimbs and 3.74-fold in forelimbs) increased sensitivity to Sema3A repulsion in Ngfr^tm1Jae homozygotes is alleviated
Genotype	Allelic Composition	Genetic Background
tg17	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6
nervous system abnormal olfactory nerve morphology (J:124050) following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored
Genotype	Allelic Composition	Genetic Background
tg18	Ngfr^tm1Jae/Ngfr⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6
nervous system abnormal olfactory nerve morphology (J:124050) following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)
Genotype	Allelic Composition	Genetic Background
tg19	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S4/SvJae * C57BL/6
nervous system abnormal olfactory nerve morphology (J:124050) the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated

References

Original:	J:43748 Lee KF et al., "Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system." Cell 1992 May 29;69(5):737-49
All:	124 reference(s)

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