Ldlr<tm1Her> Targeted Allele Detail MGI Mouse (MGI:1857212)

Ldlr^tm1Her
Targeted Allele Detail

Nomenclature

Symbol:	Ldlr^tm1Her
Name:	low density lipoprotein receptor; targeted mutation 1, Joachim Herz
MGI ID:	MGI:1857212
Synonyms:	LDLR KO, LDLR-, LDLr0, LDLrKO, Ldlrtm1Her
Gene:	Ldlr Location: Chr9:21528038-21554360 bp, + strand Genetic Position: Chr9, 5.0 cM

Phenotype of aortic arch atherosclerotic lesions in Tbx21^tm1Glm/Tbx21^tm1Glm Ldlr^tm1Her/Ldlr^tm1Her and Ldlr^tm1Her/Ldlr^tm1Her mice

Show the 7 image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:37394
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:	Targeted (knock-out)
Mutation:	Insertion
	Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. (J:37394)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 16 strains available Cell Lines: 0 lines available
Carrying any Ldlr Mutation:	33 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found