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Ifngtm1Ts
Targeted Allele Detail

Nomenclature
Symbol: Ifngtm1Ts
Name: interferon gamma; targeted mutation 1, Timothy Stewart
MGI ID: MGI:1857184
Synonyms: GKO, ifgtm1, IFN-g KO, Ifn-gtm1Ts, IFN-gamma KO, IFN-gamma-, IFN-gammatm1Ts, IFN-gammaKO, Ifntm/Ts, ifntm1Ts, ifng-, Ifngtm1Ts, IFNgamma KO, IFNgamma-, Ifngtm1Ts
Gene: Ifng   Location: Chr10:117878103-117882948 bp, + strand    Genetic Position: Chr10, 67.0 cM
Mutation
origin
Germline Transmission: Earliest citation of germline transmission: J:66802
Parent Cell Line: AB1 (ES Cell)
Strain of Origin: 129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type: Targeted (knock-out)
Mutation: Insertion
  Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. (J:66802)
Inheritance: Recessive
Find Mice (IMSR) Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation: Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation: 9 strains or lines available
Expression
In Mice Carrying this Mutation: 2 assay results
Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

      Key:  
hm homozygous ht heterozygous
cn conditional genotype  cx complex: > 1 genome feature
tg involves transgenes ot other: hemizygous, indeterminate,...
N normal phenotype expected model not found
Affected SystemsGenotypes:
 
hm1
 
hm2
 
hm3
 
hm4
 
hm5
 
hm6
 
cx7
 
cx8
 
cx9
 
cx10
 
cx11
 
cx12
  
cardiovascular system          		 √         √
  
cellular          		√           
  
digestive/alimentary system          		√    √ √    
  
endocrine/exocrine glands          		     √      
  
growth/size          		      √     
  
hematopoietic system          		√ √     √   
  
homeostasis/metabolism          		√√    √    √
  
immune system          		√√√√√√√√√√√√
  
lethality/postnatal          		      √ √   
  
life span/aging          		        √  √
  
liver/biliary system          		      √     
  
renal/urinary system          		          √√
  
respiratory system          		          √ 
  
tumorigenesis          		  √     √   
  
vision/eye          		 √          
 
  
Disease Models          		    √√     
Phenotypic
data by
genotype
Phenotypic Data by Genotype

(show or hide all phenotypic details)

GenotypeAllelic CompositionGenetic Background
  
 hm1   		 Ifngtm1Ts/Ifngtm1Ts B6.129S7-Ifngtm1Ts/J
  
 hm2   		 Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd
  
 hm3   		 Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * C57BL/6
  
 hm4   		 Ifngtm1Ts/Ifngtm1Ts NOD-Ifngtm1Ts
  
 hm5   Disease Model  		 Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts Prkdcscid
  
 hm6   Disease Model  		 Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts/DvsJ
  
 cx7   		 Ifngtm1Ts/Ifngtm1Ts
Tgfb1tm1Doe/Tgfb1tm1Doe		 C.129-Ifngtm1Ts Tgfb1tm1Doe
  
 cx8   		 Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J
  
 cx9   		 Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
  
 cx10   		 Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Jni/Socs1tm1Jni		 involves: 129S7/SvEvBrd
  
 cx11   		 Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts		 MRL.Cg-Ifngtm1Ts Faslpr
  
 cx12   		 Faslpr/Faslpr
Ifngtm1Ts/Ifng+		 MRL.Cg-Ifngtm1Ts Faslpr
Disease
models
Mouse Models
of Human Disease
NoteGenotypeRef(s)
 
Allelic Composition
Genetic Background
Models with phenotypic similarity to human diseases not associated with human IFNG.
Diabetes Mellitus, Insulin-Dependent; IDDM
OMIM ID: 222100		  
 
hm6		Ifngtm1Ts/Ifngtm1TsNOD.129S7(B6)-Ifngtm1Ts/DvsJJ:72818
 
 
hm5		Ifngtm1Ts/Ifngtm1TsNOD.129S7(B6)-Ifngtm1Ts PrkdcscidJ:72818
No similarity to expected human disease phenotype was found.1
NOT Systemic Lupus Erythematosus; SLE
OMIM ID: 152700		  
 
cx9		Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli		involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J:83086
1One or more human genes may be associated with the human disease. The mouse genotype may involve mutations in orthologous genes, but the phenotype did not resemble the human disease.
References
Original: J:66802 Dalton DK et al., "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]" Science 1993 Mar 19;259(5102):1739-42
All: 586 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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11/20/2009
MGI_4.31
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