Apoe<tm1Unc> Targeted Allele Detail MGI Mouse (MGI:1857129)

Apoe^tm1Unc
Targeted Allele Detail

Nomenclature

Symbol:	Apoe^tm1Unc
Name:	apolipoprotein E; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857129
Synonyms:	AopE(-), APOE KO, apoE-, ApoE-KO, Apoe^tm1Un, apoE0, epsilon-
Gene:	Apoe Location: Chr7:20281621-20284381 bp, - strand Genetic Position: Chr7, 4.0 cM

Morphology of aortic lesions in Apoe^tm1Unc/Apoe^tm1Unc and Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far mice

Show the 5 image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:1050
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:	Targeted (knock-out)
Mutations:	Insertion, Intragenic deletion
	Insertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE. (J:1050)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 16 strains available Cell Lines: 0 lines available
Carrying any Apoe Mutation:	39 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found