gr Spontaneous Allele Detail MGI Mouse (MGI:1856888)

gr
Spontaneous Allele Detail

Nomenclature

Symbol:	gr
Name:	grizzled
MGI ID:	MGI:1856888
Gene:	gr Location: unknown Genetic Position: Chr10, 43.0 cM

control and gr/gr

Show the 1 image(s) involving this allele.

Mutation
origin

Strain of Origin:

A x STOCK-Sgk3^fz

Mutation
description

Allele Type:	Spontaneous
Mutation:	Undefined
	This allele maps to a region of homology with the human paralemmin gene, PALM. Direct sequencing of RNA from brains of homozygous mice and analysis of the paralemmin coding region showed no sequence abnormalities. (J:47933)
Inheritance:	Recessive

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any gr Mutation:	2 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	cx2
craniofacial		√
abnormal craniofacial bone morphology		√
abnormal skull morphology		√
abnormal jaw morphology		√
abnormal orbital bone morphology		√
		hm1	cx2
growth/size		√
abnormal postnatal growth/weight/body size		√
abnormal body weight		√
decreased body weight		√
decreased body size		√
		hm1	cx2
lethality/postnatal		√
postnatal lethality		√
		hm1	cx2
lethality/prenatal-perinatal		√
prenatal lethality		√
		hm1	cx2
life span/aging		√
premature death		√
		hm1	cx2
limbs/digits/tail		√
abnormal tail morphology		√
kinked tail		√
		hm1	cx2
nervous system			√
abnormal brain wave pattern			√
		hm1	cx2
pigmentation		√
absent coat pigmentation		√
diluted coat color		√
		hm1	cx2
reproductive system		√
abnormal ovulation		√
decreased ovulation frequency		√
		hm1	cx2
skeleton		√
abnormal skeleton morphology		√
abnormal craniofacial bone morphology		√
abnormal skull morphology		√
abnormal jaw morphology		√
abnormal orbital bone morphology		√
		hm1	cx2
skin/coat/nails		√
absent coat pigmentation		√
diluted coat color		√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	gr/gr	involves: A * STOCK fz
lethality/prenatal-perinatal prenatal lethality (J:11987) some survive to birth cranial-facial defects commonly seen may contribute to mortality lethality/postnatal postnatal lethality (J:11987) some mutants survive to maturity more females than males survive pigmentation absent coat pigmentation (J:24769) on a non-agouti background hairs on the ears and genitalia normally yellow are white diluted coat color (J:11987) dilutes yellow pigment (phaeomelanin) agouti mice look like chinchilla (A/A;c^ch/c^ch) growth/size abnormal postnatal growth/weight/body size (J:11987) abnormal body weight (J:11987) weight is 25% less than normal at birth and remains 10-20% below weight of normal littermates decreased body size (J:11987) reduced body size 20-30% smaller than normal littermates at birth 10% smaller than normal littermates as adults decreased body weight (J:11987) weight data between 2 and 6 weeks of age show females are 75-80% of normal weight; males are 90-95% of normal weight skin/coat/nails absent coat pigmentation (J:24769) on a non-agouti background hairs on the ears and genitalia normally yellow are white diluted coat color (J:11987) dilutes yellow pigment (phaeomelanin) agouti mice look like chinchilla (A/A;c^ch/c^ch) skeleton abnormal skeleton morphology (J:11987) abnormal craniofacial bone morphology (J:11987) commom among E16-18 fetuses; not seen among pups after birth abnormal skull morphology (J:11987) abnormal jaw morphology (J:11987) most frequent abnormaity among E16-18 fetuses; not seen among pups after birth abnormal orbital bone morphology (J:11987) frequently seen among E16-18 fetuses; not seen among pups after birth craniofacial abnormal craniofacial bone morphology (J:11987) commom among E16-18 fetuses; not seen among pups after birth abnormal skull morphology (J:11987) abnormal jaw morphology (J:11987) most frequent abnormaity among E16-18 fetuses; not seen among pups after birth abnormal orbital bone morphology (J:11987) frequently seen among E16-18 fetuses; not seen among pups after birth reproductive system abnormal ovulation (J:11987) decreased ovulation frequency (J:11987) although low compared to normal, ovulation rate is consistent with smaller size of mutant mice limbs/digits/tail abnormal tail morphology (J:11987) kinked tail (J:11987) occasionally seen life span/aging premature death (J:11987) mortality occurs at all stages with loss of 50-60% of mutants
Genotype	Allelic Composition	Genetic Background
cx2	Ap3d1^mh gr⁺/Ap3d1⁺ gr	STOCK gr +/+ Ap3d1^mh/J
nervous system abnormal brain wave pattern (J:96307) electrocorticograms of mocha heterozygotes show occasional brief bursts of lower voltage theta waves, which are a less pronounced abnormality than in homozygotes

References

Original:	J:24769 Falconer DS, "Mutant stocks" Mouse News Lett 1950;2():3
All:	9 reference(s)

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