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| Nomenclature |
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Symbol:
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Fgfr2svs
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Name:
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fibroblast growth factor receptor 2;
seminal vesicle shape
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MGI ID: |
MGI:1856633 |
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Synonyms: |
svs |
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Gene:
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Fgfr2
Location:
Chr7:137305965-140315033 bp, - strand
Genetic Position: Chr7,
62.0 cM
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Mutation
origin |
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Strain of Origin:
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CXB5/By
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Viral insertion |
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An insertion of a 491-bp mouse leukemia virus long terminal repeat (MLV-LTR) sequence into intron 10 results in aberrant alternative splicing of the transcript with exclusion from most mature mutant mRNA species of exon 8IIIb, which encodes the domain required for specific binding to FGF ligands in developing prostate and seminal vesicle mesenchyme.
(J:119935) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
Seminiferous tubules in male mice of the CXBI/ByEss recombinant inbred strain were found to be tubular and smooth, in contrast to normal mice such as C57BL/6By males, in which the seminal vesicles are curved and convoluted. A recessive autosomal mutation apparently occurred early in the inbreeding of the CXB recombinant inbred lines, as the abnormality was not present in either of the parental strains, C57BL/6ByEss or BALB/cByEss, but is present in both CXBI/ByJax and CXBI/ByLac. The mutation has been given the name and symbol seminal vesicle shape, svs. It appears to be linked to Tyr on Chr 7. In segregating crosses, svs/svs homozygotes had slightly lighter seminal vesicles than normal, though the weights of other androgen target organs were not reduced. Seminal vesicles responded to exogenous testosterone by increased size, but their shape did not change. The protein pattern under SDS--acrylamide gel electrophoresis differed between parent lines, but was not affected by the svs gene. A difference in the electrophoretic pattern for 27 kDa proteins was attributed to a new gene, Svp4 (J:9441).
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| References |
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Original: |
J:64453
Shukri N et al.,
"svs - seminal vesicle shape"
Mouse News Lett 1988;81():56
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All: |
4 reference(s)
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