Aft Spontaneous Allele Detail MGI Mouse (MGI:1856589)

Aft
Spontaneous Allele Detail

Nomenclature

Symbol:	Aft
Name:	abnormal feet and tail
MGI ID:	MGI:1856589
Gene:	Aft Location: unknown Genetic Position: Chr9, 32.0 cM

Phenotypes of Aft mutation

Show the 2 image(s) involving this allele.

Mutation
origin

Strain of Origin:

129S1/Sv-Kit^W-54J Tyr^c-ch

Mutation
description

Allele Type:	Spontaneous
Inheritance:	Semidominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Aft Mutation:	1 strain or line available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	ht1	ht2
limbs/digits/tail		√	√
syndactyly		√	√
interdigital webbing			√
kinked tail		√	√
		ht1	ht2
skin/coat/nails			√
disheveled coat			√
decreased hair follicle number			√
alopecia			√
skin lesions			√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
ht1	Aft/Aft⁺	involves: 129S1/Sv
limbs/digits/tail syndactyly (J:12972) syndactyly of digits 3 and 4 of the hindfeet, 50% penetrance kinked tail (J:12972) 50% penetrance
Genotype	Allelic Composition	Genetic Background
ht2	Aft/Aft⁺	involves: 129S1/Sv * C57BL/6J
Phenotypes of Aft mutation skin/coat/nails disheveled coat (J:81166) at around 6-8 months of age, when local hair loss begins, the fur appears clumpy and unkempt decreased hair follicle number (J:81166) skin shows focal areas of decreased hair follicle density with fibrous tracts, pigment incontinence and increased mast cells alopecia (J:81166) incompletely penetrant progressive late-onset hair loss (around 6-8 months of age) that starts locally around the snout and back of ears skin lesions (J:81166) late-onset (6-8 months of age) of skin lesions following hair loss that progress into bleeding ulcerations limbs/digits/tail syndactyly (J:81166) partial syndactyly of digits 3 and 4 on the hindlimbs, commonly unilateral several mutants are seen in which digits other than 3 and 4 are fused interdigital webbing (J:81166) syndactyly is caused by the persistence of the skin web between the digits and not due to fused bony elements kinked tail (J:81166) tail kinks are most likely caused by varying degrees of cartilage overgrowth and fusion and a dysmorphogenesis of bony elements attached to the fusion site

References

Original:	J:12972 Lane PW, "Abnormal feet and tail (Aft)" Mouse News Lett 1987;78():56-57
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/20/2009 MGI_4.31 Web browser compatibility