A Spontaneous Allele Detail MGI Mouse (MGI:1856464)

A
Spontaneous Allele Detail

Nomenclature

Symbol:	A
Name:	nonagouti; wild type agouti
MGI ID:	MGI:1856464
Synonyms:	dark-bellied agouti
Gene:	a Location: Chr2:154617138-154876748 bp, + strand Genetic Position: Chr2, 89.0 cM

Mutation
origin

Strain of Origin:

various

Mutation
description

Allele Type:	Spontaneous
Mutation:	Other
	This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. (J:3523)
Inheritance:	Dominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 26 strains available Cell Lines: 0 lines available
Carrying any a Mutation:	314 strains or lines available

Expression

In Mice Carrying this Mutation:

16 assay results

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems

Genotypes:

adipose tissue

√

behavior/neurological

√

growth/size

√

homeostasis/metabolism

√

liver/biliary system

√

pigmentation

√

skin/coat/nails

√

Disease Models

√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

ht1 Disease Model

A^iy/A

C3H/HeJ-A^iy

ht2

A^w-47J/A

C57BL/6J

ht3 Disease Model

A^y/A

involves: C57BL/6

ht4

A^y-Jkn/A

involves: C57BL/6N

ht5

A/a^twp

Not Specified

cx6

a/A
Pomc^tm1Sora/Pomc^tm1Sora

involves: 129S6/SvEvTac

cx7

A^y/A
Prkar2b^tm2Gsm/Prkar2b^tm2Gsm

involves: C57BL/6

cx8

A^y/A
Prkar2b^tm2Gsm/Prkar2b⁺

involves: C57BL/6

cx9

A^y-Jkn/A
Mc1r^e/Mc1r^e

involves: C57BL/6Ha * C57BL/6N

cx10

A^vy/A
Smchd1^MommeD1/Smchd1⁺

involves: C57BL/6J * FVB/NJ

cx11

A^vy/A
Dnmt1^MommeD2/Dnmt1⁺

involves: C57BL/6J * FVB/NJ

cx12

A^vy/A
Smarca5^MommeD4/Smarca5⁺

involves: C57BL/6J * FVB/NJ

cx13

A/a
Myo5a^d/Myo5a⁺
Oca2^p/Oca2⁺
Tyrp1^B-lt/Tyrp1⁺

involves: C58 * CT/Ch

cx14

A/a
Tyrp1^B-lt/Tyrp1^B-lt

Not Specified

cx15

A/A
U/U

Not Specified

tg16

a/A
Mc1r^e/Mc1r^e
Pomc^tm1Sora/Pomc^tm1Sora
Tg(MC1R)1Jkn/?

involves: 129S6/SvEvTac * C57BL/6Ha

tg17

A^y-Jkn/A
Mc1r^e/Mc1r^e
Tg(MC1R)1Jkn/0

involves: C57BL/6Ha * C57BL/6N

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
			Allelic Composition	Genetic Background
Models with phenotypic similarity to human diseases not associated with human ASIP.
Obesity OMIM ID: 601665		ht1	A^iy/A	C3H/HeJ-A^iy	J:30922
		ht3	A^y/A	involves: C57BL/6	J:131039

Notes

The A allele is usually regarded as a wild-type allele. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.

References

Original:	J:46318 Dry FW, "The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus)." J Genet 1928;20():131-144
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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