Kitl<Sl-18H> Radiation induced Allele Detail MGI Mouse (MGI:1856366)

Kitl^Sl-18H
Radiation induced Allele Detail

Nomenclature

Symbol:	Kitl^Sl-18H
Name:	kit ligand; steel 18 Harwell
MGI ID:	MGI:1856366
Gene:	Kitl Location: Chr10:99478264-99563047 bp, + strand Genetic Position: Chr10, 57.0 cM

Mutation
origin

Strain of Origin:

(C3H/HeH x 101/H)F1

Mutation
description

Allele Type:	Radiation induced
Mutation:	Deletion
	This allele comprises a deletion that is cytologically apparent, removing ~2.5% of Chr 10. Southern blot analysis and pulsed field gel electrophoresis showed that this deletion is greater than 810kb. (J:3564, J:10748, J:31566)
Inheritance:	Semidominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Kitl Mutation:	60 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	ht2	ht3	cx4
endocrine/exocrine glands					√
decreased testis weight					√
		hm1	ht2	ht3	cx4
hematopoietic system			√
anemia			√
		hm1	ht2	ht3	cx4
lethality/postnatal			N
lethality/postnatal phenotype			N
		hm1	ht2	ht3	cx4
lethality/prenatal-perinatal		√
embryonic lethality		√
embryonic lethality before somite formation		√
		hm1	ht2	ht3	cx4
pigmentation			√	√
diluted coat color			√	√
head blaze			√	√
white spotting			√
belly spot			√
head spot			√
hypopigmentation			√
		hm1	ht2	ht3	cx4
reproductive system					√
decreased testis weight					√
		hm1	ht2	ht3	cx4
skin/coat/nails			√	√
diluted coat color			√	√
head blaze			√	√
white spotting			√
belly spot			√
head spot			√
pallor			√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	Kitl^Sl-18H/Kitl^Sl-18H	involves: 101/H * C3H/HeH
lethality/prenatal-perinatal embryonic lethality (J:18280) embryonic lethality before somite formation (J:18280)
Genotype	Allelic Composition	Genetic Background
ht2	Kitl^Sl-18H/Kitl⁺	involves: 101/H * C3H/HeH
pigmentation diluted coat color (J:18280) greyish coat head blaze (J:18280) in combination with Kitl^Sl-con there is a prominent white head blaze white spotting (J:18280) head spotting and occasional nose and belly spotting belly spot (J:18280) occasional belly spot head spot (J:18280) hypopigmentation (J:18280) ears and tail are pale lethality/postnatal lethality-postnatal (J:18280) small, pale young seen at birth likely comprise the 40% loss of heterozygotes from heterozygous matings skin/coat/nails diluted coat color (J:18280) greyish coat head blaze (J:18280) in combination with Kitl^Sl-con there is a prominent white head blaze white spotting (J:18280) head spotting and occasional nose and belly spotting belly spot (J:18280) occasional belly spot head spot (J:18280) pallor (J:18280) hematopoietic system anemia (J:18280) pale offspring are presumed to be slightly anemic
Genotype	Allelic Composition	Genetic Background
ht3	Kitl^Sl-18H/Kitl^Sl-con	Not Specified
pigmentation diluted coat color (J:18280) pale grey coat color head blaze (J:18280) compound heterozygote displays a prominant white head blaze skin/coat/nails diluted coat color (J:18280) pale grey coat color head blaze (J:18280) compound heterozygote displays a prominant white head blaze
Genotype	Allelic Composition	Genetic Background
cx4	Kitl^Sl-18H/Kitl⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J
endocrine/exocrine glands decreased testis weight (J:133266) Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal reproductive system decreased testis weight (J:133266) Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

References

Original:	J:18280 Cattanach BM et al., "A new steel allele with early post-implantation homozygous lethality" Mouse News Lett 1988;80():157-58
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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