Yaa Spontaneous Allele Detail MGI Mouse (MGI:1856277)

Yaa
Spontaneous Allele Detail

Nomenclature

Symbol:	Yaa
Name:	accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
MGI ID:	MGI:1856277
Synonyms:	Tp(X;Y)1Ekw
Gene:	Yaa Location: unknown Genetic Position: ChrY, Syntenic

Mutation
origin

Strain of Origin:

SB/Le

Mutation
description

Allele Type:	Spontaneous
Mutation:	Insertion
	A region of the X chromosome that includes Tlr7 and Prps2 is translocated to the Y chromosome. (J:111064, J:140028)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Yaa Mutation:	5 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems

Genotypes:

cardiovascular system

growth/size

√

hematopoietic system

√

homeostasis/metabolism

√

immune system

√

life span/aging

√

renal/urinary system

√

skin/coat/nails

√

touch/vibrissae

√

tumorigenesis

√

Disease Models

√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

cx1

Bxs6^BXSB/MpJ/Bxs6^BXSB/MpJ
X/Yaa

B10.BXSB-(D13Mit3-D13Mit78) Yaa

cx2

Nba2^NZB/Nba2^NZB
Tlr7^tm1Aki/Y
X/Yaa

B6.Cg-Nba2^NZB Tlr7^tm1Aki Yaa

cx3

Il21r^tm1Wjl/Il21r^tm1Wjl
X/Yaa

BSXB.Cg-Il21r^tm1Wjl Yaa/Dcr

cx4

ll/ll
X/Yaa

BXSB/MpJScr-ll

cx5

Nba2^NZB/Nba2^NZB
X/Yaa

C57BL/6-Nba2 Yaa

cx6 Disease Model

Dsg4^hage/Dsg4^hage
Fas^lpr/Fas^lpr
X/Yaa

EOD-Dsg4^hage

cx7

Fcgr2b^tm1Ttk/Fcgr2b⁺
Yaa/0

involves: 129S4/SvJae * C57BL/6 * SB/Le

ot8

X/Yaa

(C57BL/6J x BXSB)F1

ot9 Disease Model

X/Yaa

(NZB x BXSB)F1

ot10

X/Yaa

(NZB x C57BL/6-Yaa)F1

ot11 Disease Model

X/Yaa

(NZW x BXSB)F1

ot12 Disease Model

X/Yaa

(NZW x SB)F1

ot13

X/Yaa

(SJL/J x BXSB)F1

ot14 Disease Model

X/Yaa

BXSB

ot15 Disease Model

X/Yaa

BXSB/MpJScr

ot16

X/Yaa

involves: BXSB * NZB

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
Mouse Models of Human Disease	Note		Allelic Composition	Genetic Background	Ref(s)
Models involving transgenes or other mutation types.¹
Hypotrichosis, Localized, Autosomal Recessive 1; LAH1 OMIM ID: 607903		cx6	Dsg4^hage/Dsg4^hage Fas^lpr/Fas^lpr X/Yaa	EOD-Dsg4^hage	J:140028
Systemic Lupus Erythematosus; SLE OMIM ID: 152700		ot14	X/Yaa	BXSB	J:108760, J:7308
		ot11	X/Yaa	(NZW x BXSB)F1	J:7276
		ot	X/Yaa	BXSB/Mp	J:6235
		ot12	X/Yaa	(NZW x SB)F1	J:7276
		ot9	X/Yaa	(NZB x BXSB)F1	J:6235
		ot15	X/Yaa	BXSB/MpJScr	J:10973

¹Models involving transgenes or other mutation types may also appear in other sections of the table.

Notes

In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.

References

Original:	J:6235 Murphy ED et al., "A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation." Arthritis Rheum 1979 Nov;22(11):1188-94
All:	57 reference(s)

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