T<Orl> Spontaneous Allele Detail MGI Mouse (MGI:1856189)

T^Orl
Spontaneous Allele Detail

Nomenclature

Symbol:	T^Orl
Name:	brachyury; T-Orleans
MGI ID:	MGI:1856189
Synonyms:	T(t-Orl>
Gene:	T Location: Chr17:8627288-8635361 bp, + strand Genetic Position: Chr17, 4.02 cM

Mutation
origin

Strain of Origin:

Orl:Swiss

Mutation
description

Allele Type:	Spontaneous
Mutation:	Deletion
	The deletion comprising this allele includes T through, at least, Qk as all short-tailed mice from matings of T^Orl/+ males to Qk^qk/Qk^qk females have a "quaking" phenotype. In addition this allele expresses the t- haplotype specific proteins p63/6.9a, TCP-4B, TCP-5, TCP-9, and TCP-8B. (J:6957)
Inheritance:	Semidominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any T Mutation:	45 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	ht1	ht2	cx3	tg4
behavior/neurological				√
abnormal motor capabilities/coordination/movement				√
abnormal involuntary movement				√
tremors				√
		ht1	ht2	cx3	tg4
limbs/digits/tail			√	√
abnormal tail morphology			√	√
short tail			√	√
		ht1	ht2	cx3	tg4
reproductive system		√			√
primary sex reversal		√			√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
ht1	T^Orl/T⁺	B6.Cg-T^Orl/EiJ
reproductive system primary sex reversal (J:71077) Background Sensitivity: on a B6 background, mice carrying this allele and a Y chromosome from AKR, LEWES/Ei, MA/MyJ, PL/J, RF/J, or the WSB/Ei inbred strain develop as infertile females on a B6 background, mice carrying this allele and a Y chromosome derived from BUB/BnJ, C57BL/6JEi, SJL/J, ST/bJ, or the SWR/J inbred strain develop as males
Genotype	Allelic Composition	Genetic Background
ht2	T^Orl/T⁺	involves: C57BL/6J * Orl:Swiss
limbs/digits/tail abnormal tail morphology (J:15078) short tail (J:15078)
Genotype	Allelic Composition	Genetic Background
cx3	T^Orl/T⁺ Qk^qk/Qk⁺	involves: C57BL/6J * Orl:Swiss
behavior/neurological abnormal motor capabilities/coordination/movement (J:15078) abnormal involuntary movement (J:15078) tremors (J:15078) mice heterozygous for T and Qk display tremors characteristic of the recessive mutation QK, demonstrating that T comprises a deletion limbs/digits/tail abnormal tail morphology (J:15078) short tail (J:15078)
Genotype	Allelic Composition	Genetic Background
tg4	T^Orl/T⁺ Tg(Sry)1Ei/0	B6.Cg-T^Orl/EiJ
reproductive system primary sex reversal (J:71077) chromosomal females carrying this transgene develop as males chromosomal males with a C57BL/6 background and an AKR Y chromosome develop as sex-reversed female; in the presence of this transgene testes develop

References

Original:	J:15078 Moutier R, "t" Mouse News Lett 1973;49():42
All:	5 reference(s)

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