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| Nomenclature |
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Symbol:
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KitlSl-con
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Name:
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kit ligand;
contrasted
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MGI ID: |
MGI:1856163 |
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Synonyms: |
Mgf |
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Gene:
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Kitl
Location:
Chr10:99478264-99563047 bp, + strand
Genetic Position: Chr10,
57.0 cM
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Mutation
origin |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: |
Radiation induced |
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Mutation: |
Other |
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Pulse field gel electrophoresis using cDNA and genomic clones showed that this allele is an undefined rearrangement between 90 and 2.2Mb 5' to Kitl. Northern analysis showed that the mRNA transcript is of normal size but this allele exerts tissue-specific effects on transcript abundance. (J:23593) |
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Inheritance: |
Semidominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
The contrasted mutation was found in a neutron irradiation experiment. Heterozygotes are recognizable soon after birth by dark pigmentation of the genital papilla. The adult coat is slightly lighter than normal. Homozygotes also have dark external genitalia but a markedly diluted coat; they have a mild macrocytic anemia. Males are fertile but females are usually sterile (J:20215). The mutation was shown to be allelic to steel by linkage and complementation tests (J:13654). The cause of the Kitl mutation is a DNA rearrangement 5' from the Kitl coding region which disrupts initiation and maintenance of ovarian follicle development (J:23593.
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| References |
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