Hr<hr> Spontaneous Allele Detail MGI Mouse (MGI:1856057)

Hr^hr
Spontaneous Allele Detail

Nomenclature

Symbol:	Hr^hr
Name:	hairless
MGI ID:	MGI:1856057
Synonyms:	hr
Gene:	Hr Location: Chr14:70953863-70973345 bp, + strand Genetic Position: Chr14, 40.0 cM

Hr^hr/Hr^hr

Show the 3 image(s) involving this allele.

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:	Spontaneous
Mutation:	Viral insertion
	The hr allele is the result of a retroviral integration. Insertion of murine leukemia proviral sequences into intron 6 results in aberrant splicing of the gene. (J:9252, J:19624, J:92053)
Inheritance:	Recessive

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Hr Mutation:	19 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
behavior/neurological			√
abnormal nursing			√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
cellular						√	√		√
increased cell proliferation						√	√
decreased cell proliferation									√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
endocrine/exocrine glands			√
abnormal mammary gland morphology			√
sebaceous gland atrophy			√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
growth/size				√
decreased birth body size				√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
hearing/vestibular/ear		√
absent linear vestibular evoked potential		√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
hematopoietic system		√
decreased T cell number		√
increased macrophage cell number		√
decreased T cell proliferation		√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
homeostasis/metabolism						√	√		√
decreased prostaglandin level						√	√
increased prostaglandin level									√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
immune system		√
decreased T cell number		√
increased macrophage cell number		√
decreased T cell proliferation		√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
lethality/postnatal				√
postnatal lethality				√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
life span/aging					√
premature death					√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
liver/biliary system				√
abnormal hepatocyte morphology				√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
reproductive system			√
abnormal mammary gland morphology			√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
skin/coat/nails			√	√				√
alopecia			√
deformed nails			√
abnormal skin morphology			√
abnormal dermis reticular layer morphology			√
dermal cysts			√
hyperkeratosis			√
epidermal hyperplasia			√
increased sensitivity to skin irradiation				√
increased resistance to skin irradiation								√
		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
tumorigenesis		√		√		√	N	√	√
tumorigenesis phenotype							N
leukemia		√
increased incidence of UV-induced tumors				√					√
decreased incidence of UV-induced tumors						√		√
squamous cell carcinoma								√

		hm1	hm2	cn3	cx4	cx5	cx6	tg7	tg8
Disease Models			√
Alopecia Universalis Congenita; ALUNC			√
Atrichia with Papular Lesions; APL			√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype

Allelic Composition

Genetic Background

hm1

Hr^hr/Hr^hr

HRS/J

hm2 Disease Model

Hr^hr/Hr^hr

Not Specified

cn3

Ercc1^tm1Dwm/Ercc1^tm2Dwm
Hr^hr/Hr^hr
Tg(KRT1-5-cre)5132Jlj/0

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

cx4

Hr^hr/Hr^hr
Ptgs2^tm1Unc/Ptgs2^tm1Unc

involves: 129P2/OlaHsd * C57BL/6 * SKH1

cx5

Hr^hr/Hr^hr
Ptgs2^tm1Unc/Ptgs2⁺

involves: 129P2/OlaHsd * C57BL/6 * SKH1

cx6

Hr^hr/Hr^hr
Ptgs1^tm1Unc/Ptgs1⁺

involves: 129P2/OlaHsd * C57BL/6 * SKH1

tg7

Hr^hr/Hr^hr
Tg(KRT14-Birc5)19Gros/0

involves: C3H * C57BL/6 * SKH1

tg8

Hr^hr/Hr^hr
Tg(KRT14-Ptgs2)1Sumf/0

involves: C57BL/6 * DBA/2 * FVB * SKH1

Disease
models

Mouse Models of Human Disease	Note	Genotype			Ref(s)
			Allelic Composition	Genetic Background
Models with phenotypic similarity to human diseases associated with human HR.
Alopecia Universalis Congenita; ALUNC OMIM ID: 203655		hm2	Hr^hr/Hr^hr	Not Specified	J:2409
Atrichia with Papular Lesions; APL OMIM ID: 209500		hm2	Hr^hr/Hr^hr	Not Specified	J:2409

References

Original:	J:2405 Brooke HC, "Hairless mice" J Hered 1926;17():173-74
All:	68 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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