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| Nomenclature |
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Symbol:
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Mc1rE-tob
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Name:
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melanocortin 1 receptor;
tobacco darkening
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MGI ID: |
MGI:1856030 |
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Synonyms: |
Etob |
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Gene:
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Mc1r
Location:
Chr8:125930982-125934642 bp, + strand
Genetic Position: Chr8,
68.0 cM
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Mutation
origin |
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Strain of Origin:
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M. m. domesticus poschiavinus
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Single point mutation |
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Two independent PCR assays found a C-to-T mutation at position 206 predicted to result in a serine to leucine alteration in codon 69. A second nucleotide C-to-T change results in a silent mutation at position 166. (J:4636) |
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Inheritance: |
Semidominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Mc1rE-tob/Mc1rE-tob |
M. m. domesticus poschiavinus |
pigmentation skin/coat/nails |
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Notes |
Mc1rE-tob, tobacco darkening, semidominant. Formerly Etob. Mice of the species Mus poschiavinus, the tobacco mouse, are homozygous for this allele. They are black in color until the eighth week, after which the flanks become agouti. In descendants from crosses with Mus musculus, Mc1rE-tob/+ heterozygotes show an agouti pattern with darkened back. Mc1rE-tob/Mc1re a/a mice are black (J:22593, J:13641). The Mc1rE-tob allele carries two point mutations that result in a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele (J:4636).
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| References |
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Original: |
J:22593
von Lehmann E,
"Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio)"
Mouse News Lett 1973;48():23
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All: |
6 reference(s)
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