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| Nomenclature |
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Symbol:
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Myo5ad-l
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Name:
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myosin VA;
dilute lethal
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MGI ID: |
MGI:1856005 |
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Synonyms: |
dl |
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Gene:
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Myo5a
Location:
Chr9:74918822-75071495 bp, + strand
Genetic Position: Chr9,
42.0 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/Gr
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
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Myo5ad-l/Myo5ad-l |
C57BL |
behavior/neurological muscle nervous system pigmentation skin/coat/nails |
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Notes |
Myo5ad-l, dilute-lethal, recessive. Dilute-lethal arose in the C57BL/Gr strain. The color of Myo5ad-l homozygotes is identical to that of Myo5ad homozygotes, but dilute-lethal mice develop a severe neuromuscular disorder characterized by convulsions and opisthotonus (arching upward of the head and tail), and they usually die at about 3 weeks of age (J:12978).
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| References |
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Original: |
J:24768
Searle AG,
"New mutant, allele of Maltese dilution, d"
Mouse News Lett 1951;4():10
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All: |
15 reference(s)
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