Tyr<c-a> Spontaneous Allele Detail MGI Mouse (MGI:1855983)

Tyr^c-a
Spontaneous Allele Detail

Nomenclature

Symbol:	Tyr^c-a
Name:	tyrosinase; acromelanic
MGI ID:	MGI:1855983
Gene:	Tyr Location: Chr7:94577327-94641899 bp, - strand Genetic Position: Chr7, 44.0 cM

Mutation
origin

Strain of Origin:

C3H/HeJ

Mutation
description

Allele Type:	Spontaneous
Inheritance:	Recessive

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Tyr Mutation:	206 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2	ht3	ht4	ht5	ht6
homeostasis/metabolism			N
homeostasis/metabolism phenotype			N
		hm1	hm2	ht3	ht4	ht5	ht6
pigmentation		√		√	√	√	√
abnormal coat/hair pigmentation		√		√	√	√	√
abnormal eye pigmentation				√
		hm1	hm2	ht3	ht4	ht5	ht6
skin/coat/nails		√		√	√	√	√
abnormal coat/hair pigmentation		√		√	√	√	√
		hm1	hm2	ht3	ht4	ht5	ht6
vision/eye				√
abnormal eye pigmentation				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	Tyr^c-a/Tyr^c-a	C3H/HeJ
pigmentation abnormal coat/hair pigmentation (J:14994) young and adult have an off-white coat color and eyes, ears, tail and anal regions are pigmented in the albino series, coat appearance is between chinchilla and extreme dilution skin/coat/nails abnormal coat/hair pigmentation (J:14994) young and adult have an off-white coat color and eyes, ears, tail and anal regions are pigmented in the albino series, coat appearance is between chinchilla and extreme dilution
Genotype	Allelic Composition	Genetic Background
hm2	Tyr^c-a/Tyr^c-a	C3H/HeJ-Tyr^c-a/J
homeostasis/metabolism homeostasis/metabolism phenotype (J:29151) no aberrant bleeding time after tail vein nick
Genotype	Allelic Composition	Genetic Background
ht3	Tyr^c/Tyr^c-a	involves: C3H/HeJ
pigmentation abnormal coat/hair pigmentation (J:14994) slightly off-white coat color ear and tail hairs are slightly sooty abnormal eye pigmentation (J:14994) eyes are dark but no comparison to wild-type given skin/coat/nails abnormal coat/hair pigmentation (J:14994) slightly off-white coat color ear and tail hairs are slightly sooty vision/eye abnormal eye pigmentation (J:14994) eyes are dark but no comparison to wild-type given
Genotype	Allelic Composition	Genetic Background
ht4	Tyr^c-a/Tyr^c-ch	involves: C3H/HeJ
pigmentation abnormal coat/hair pigmentation (J:14994) coat color is intermediate between chinchilla and acromelanic homozygotes with a very darkly pigmented anal region skin/coat/nails abnormal coat/hair pigmentation (J:14994) coat color is intermediate between chinchilla and acromelanic homozygotes with a very darkly pigmented anal region
Genotype	Allelic Composition	Genetic Background
ht5	Tyr^c-a/Tyr^c-e	involves: C3H/HeJ
pigmentation abnormal coat/hair pigmentation (J:14994) this heterozygous compound has a lighter coat but darker ears and tail hair than Tyr^c-e homozygotes appearance is indistinguishable from Tyr^c-a homozygotes skin/coat/nails abnormal coat/hair pigmentation (J:14994) this heterozygous compound has a lighter coat but darker ears and tail hair than Tyr^c-e homozygotes appearance is indistinguishable from Tyr^c-a homozygotes
Genotype	Allelic Composition	Genetic Background
ht6	Tyr^c-a/Tyr^c-h	involves: C3H/HeJ
pigmentation abnormal coat/hair pigmentation (J:14994) the coat is lighter than mice that are homozygous Tyr^c-h but indistinguishable from acromelanic homozygotes skin/coat/nails abnormal coat/hair pigmentation (J:14994) the coat is lighter than mice that are homozygous Tyr^c-h but indistinguishable from acromelanic homozygotes

References

Original:	J:14994 Sweet HO, "Acromelanic (c<a>)" Mouse News Lett 1987;78():56
All:	5 reference(s)

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