A<w> Spontaneous Allele Detail MGI Mouse (MGI:1855936)

A^w
Spontaneous Allele Detail

Nomenclature

Symbol:	A^w
Name:	nonagouti; white-bellied agouti
MGI ID:	MGI:1855936
Synonyms:	light-bellied agouti
Gene:	a Location: Chr2:154617138-154876748 bp, + strand Genetic Position: Chr2, 89.0 cM

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:	Spontaneous
Mutation:	Transposon insertion
	Molecular cloning demonstrated that the location of an exon, 1A, responsible for the ventral-specific light (white) belly is within a 3.1-kb element that is duplicated in the opposite orientation 15-kb upstream producing an interrupted palindrome approximately 22 kb in length. (J:35710)
Inheritance:	Dominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 12 strains available Cell Lines: 0 lines available
Carrying any a Mutation:	314 strains or lines available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	ht2	ht3	ht4	cx5	cx6	ot7
endocrine/exocrine glands		√			N
endocrine/exocrine glands phenotype		N			N
abnormal x-zone morphology		√
		hm1	ht2	ht3	ht4	cx5	cx6	ot7
growth/size				√
increased body weight				√
		hm1	ht2	ht3	ht4	cx5	cx6	ot7
pigmentation						√	√	√
diluted coat color						√	√
abnormal ventral coat pigmentation								√
yellow coat color								√
		hm1	ht2	ht3	ht4	cx5	cx6	ot7
skin/coat/nails						√	√	√
diluted coat color						√	√
abnormal ventral coat pigmentation								√
yellow coat color								√
		hm1	ht2	ht3	ht4	cx5	cx6	ot7
tumorigenesis			N	√
tumorigenesis phenotype			N
decreased incidence of induced tumors				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	A^w/A^w	involves: SM/J
endocrine/exocrine glands endocrine/exocrine gland phenotype (J:19308) total cortex and x-zone of adrenal cortex are of similar thickness to a/a, A^w/a, or A^w/ A^w 70-day old virgin mice zona glomerulosa, zona fasciculata, and zona reticularis are morphologically similar between genotypes abnormal x-zone morphology (J:19308) zone contains highly vacuolated cells
Genotype	Allelic Composition	Genetic Background
ht2	A^vy/A^w	129S1.C3-A^vy/A^w Chr 19^MOLF/Ei
tumorigenesis tumorigenesis (J:146879) mice exhibit the same incidence of testicular germ cell tumors as in 129S1/SvImJ-Chr 19/Na mice
Genotype	Allelic Composition	Genetic Background
ht3	A^y/A^w	129S1.C3-A^y/A^w Chr 19^MOLF/Ei
tumorigenesis decreased incidence of induced tumors (J:146879) incidence of testicular germ cell tumors is decreased 24% compared to in 129S1/SvImJ-Chr 19/Na mice growth/size increased body weight (J:146879)
Genotype	Allelic Composition	Genetic Background
ht4	A^w/a	involves: SM/J
endocrine/exocrine glands endocrine/exocrine gland phenotype (J:19308) total cortex and x-zone of adrenal cortex are of similar thickness to a/a and A^w/ A^w 70-day old virgin mice X-zone is composed exclusively of non-vacuolated cells 70-day old hybrids of mixed C57BL/6 and SM/J background have non-vacuolated x-zones
Genotype	Allelic Composition	Genetic Background
cx5	A^w/a Corin^tm1Bamo/Corin^tm1Bamo	involves: 129X1/SvJ * C57BL/6 * FVB/N
skin/coat/nails diluted coat color (J:130426) Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype mice exhibit a progressively lighter coat color with additional functioning non-agouti allele pigmentation diluted coat color (J:130426) Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype mice exhibit a progressively lighter coat color with additional functioning non-agouti allele
Genotype	Allelic Composition	Genetic Background
cx6	A^w/A^w Corin^tm1Bamo/Corin^tm1Bamo	involves: 129X1/SvJ * C57BL/6 * FVB/N
skin/coat/nails diluted coat color (J:130426) Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype mice exhibit a progressively lighter coat color with additional functioning non-agouti allele pigmentation diluted coat color (J:130426) Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype mice exhibit a progressively lighter coat color with additional functioning non-agouti allele
Genotype	Allelic Composition	Genetic Background
ot7	A^w/?	Not Specified
pigmentation abnormal ventral coat pigmentation (J:22600, J:78801) belly of animal is white, cream, or tan (yellow) in color; hairs originating on ventrum may be frequently nonpigmented, possess yellow pigment or are predominantly yellow with black bases compared to A/A mice (J:78801) A^w is dominant to A and all lower alleles (J:78801) yellow coat color (J:22600) hairs on back have narrow yellow band near the tip; belly hairs are light yellow for most of their length coat is lighter in general than normal agouti coat skin/coat/nails abnormal ventral coat pigmentation (J:22600, J:78801) belly of animal is white, cream, or tan (yellow) in color; hairs originating on ventrum may be frequently nonpigmented, possess yellow pigment or are predominantly yellow with black bases compared to A/A mice (J:78801) A^w is dominant to A and all lower alleles (J:78801) yellow coat color (J:22600) hairs on back have narrow yellow band near the tip; belly hairs are light yellow for most of their length coat is lighter in general than normal agouti coat

References

Original:	J:64108 Dickie MM, "A<w> - white-bellied agouti" Mouse News Lett 1969;40():29
All:	18 reference(s)

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